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Purpose: To determine the effect of Pars Plana Vitrectomy on the central corneal thickness (CCT) and its influence on intraocular pressure (IOP). Study Design: Interventional case series. Place and Duration of Study: This research was conducted at Ibrahim Eye Hospital, Karachi, Pakistan, from October 2022 to March 2023. Methods: Forty-one patients of either sex presenting with posterior segment disease and planned for Pars Plana vitrectomy (PPV) were selected after written informed consent. Pre and post-operative comparison of CCT and IOP was done using paired t-test. Follow-up of readings was done by repeated measures ANOVA test. BCVA measurements were based on the Snellen chart and were converted to the logarithm of the minimum angle of resolution (logMAR) scale for statistical analysis. Results: CCT and IOP of the affected eyes were increased considerably in the first post-operative week (CCT = 591 ± 1.5, IOP = 28 ± 1.5) and decreased significantly in the 3rd month (CCT = 527 ± 1.34, IOP = 13 ± 2.5). The change was insignificant at 6th month follow-up. BCVA was improved in first week (626 ± 1.34) and remained same throughout the follow-up period. Maximum change in CCT (ΔCCT) was found in age < 15 years and in aphakic eyes (119 ± 0.09). Conclusion: Pars Plana vitrectomy causes significant change in CCT which can influence IOP. This change should be kept in mind to prevent false diagnosis of glaucoma in the early post-operative period of PPV. Young patients and Aphakic eyes are more prone to the corneal changes. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the role of artificial tear treatment on central corneal thickness in patients with dry eyes coming to a tertiary care eye hospital. Study Design: Quasi-experimental study. Place and Duration of Study: Tertiary Care Eye Center, Armed Forces Institute of Ophthalmology, Rawalpindi Pakistan, from May to Nov 2022. Methodology: The study included central corneal thickness of 210 eyes (n=210) of 110 patients with dry eye disease measured before and after treatment with continuous use of artificial tear drops one month apart, patients were diagnosed on the presence of symptoms such as burning, dryness, pain, irritation, grittiness followed by slit lamp examination for marginal tear meniscus(<0.25mm) or absent, tear film BUT of <10 seconds, Schrimer test 2 of <6mm after 5 minutes and ocular surface staining score of >1 with fluorescein. Central corneal thickness was measured using corneal topography (Galleli G6 Ziemer). Results: A total of two hundred and twenty eyes of 110 individuals having dry eyes were included in our study. Median CCT before treatment with artificial tears was 522(75)pm while median CCT after 1 month treatment with artificial tears was 547(22.25)pm this showed a percentage increase of 3.79% in central corneal thickness after one month treatment with artificial tears (p-value <0.001) therefore treatment with artificial tears was significantly associated with an increase in central corneal thickness in dry eye disease. Conclusion: Central corneal thickness is substantially related to dry eyes. [ABSTRACT FROM AUTHOR]