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The Pacific Ocean is among the five largest and deepest oceans in the world. The area of the Pacific Ocean covers about 28 % of the Earth's surface. This is the habitat of many marine species, and its diversity is recognized as a fundamental element of Pacific culture and heritage. The ecosystems of aquatic animals are highly affected by climate change and by other factors. Residual toxins on aquatic animals can be categorized into two types based on origin: toxins of marine origin and toxins associated with human activity. Residual toxins have emerged as a global concern in recent years due to their frequent presence in aquatic environments. Furthermore, residual toxins in organisms living in the marine environment in the Pacific Ocean region also seriously affect food safety, food security, and especially human health. In this review we discuss important issues about residual toxins on aquatic animals in the Pacific areas specifically about the types of toxins that exist in marine animals, their contamination pathways in the Asia, Pacific region and the potential health effects for humans, the application of information technology and artificial intelligence in residual toxins on aquatic animal., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)