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Your search keyword '"Stonik, Valentin A."' showing total 2 results
Start Over Author "Stonik, Valentin A." Region pacific ocean
2 results on '"Stonik, Valentin A."'

1. Pulchranins B and C, new acyclic guanidine alkaloids from the Far-Eastern marine sponge Monanchora pulchra.

Author

Makarieva TN, Ogurtsova EK, Korolkova YV, Andreev YA, Mosharova IV, Tabakmakher KM, Guzii AG, Denisenko VA, Dmitrenok PS, Lee HS, Grishin EV, and Stonik VA

Subjects
Alkaloids chemistry, Animals, Guanidines chemistry, Molecular Structure, Pacific Ocean, Alkaloids isolation & purification, Guanidines isolation & purification, Porifera chemistry, TRPV Cation Channels antagonists & inhibitors
Abstract

New marine natural products, pulchranins B and C (2 and 3), were isolated from the marine sponge Monanchora pulchra and their structures were established using NMR and MS analysis. Compounds 2 and 3 were moderately active as inhibitors of TRPV1 (EC50 value of 95 and 183 microM, respectively) and less potent against TRPV3 and TRPA1 receptors.

Published
2013

2. Phrygiasterol, a cytotoxic cyclopropane-containing polyhydroxysteroid, and related compounds from the pacific starfish Hippasteria phrygiana.

Author

Levina EV, Kalinovsky AI, Andriyashenko PV, Dmitrenok PS, Aminin DL, and Stonik VA

Subjects
Animals, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Calcium antagonists & inhibitors, Drug Screening Assays, Antitumor, Inhibitory Concentration 50, Mice, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Pacific Ocean, Spleen cytology, Spleen drug effects, Steroids chemistry, Steroids pharmacology, Tumor Cells, Cultured, Antineoplastic Agents isolation & purification, Starfish chemistry, Steroids isolation & purification
Abstract

The new cyclopropane-containing steroid phrygiasterol (1) and steroid glycoside phrygioside B (2), along with previously known borealoside C (2a) and (20R,24S)-5alpha-cholesta-3beta,6alpha,8,15alpha,24-pentaol (3), have been isolated from the Pacific starfish Hippasteria phrygiana. On the basis of spectroscopic analyses, using 1D and 2D NMR techniques and some chemical transformations, the structures of 1 and 2 have been established as (20R,24R,25R)-24,26-cyclo-5alpha-cholesta-3beta,6alpha,8,15alpha,16beta,27-hexaol (1) and the sodium salt of (20R,24S)-24-O-(3-O-methyl-4-O-sulfate-beta-d-xylopyranosyl)-5alpha-cholesta-3beta,6alpha,8,15alpha,24-pentaol (2), respectively. Compound 1 inhibited the growth of Ehrlich carcinoma cells with an IC(50) of 50 microg/mL, whereas 2 induced apoptosis of the same cells (EC(50)=70 microg/mL) and inhibited Ca(2+) influx into mouse spleenocytes (EC(50)=20microg/mL).

Published
2005
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