1. A new cyclic peptide from a marine-derived bacterium of the genus Nocardiopsis.
- Author
-
Shin J, Seo Y, Lee HS, Rho JR, and Mo SJ
- Subjects
- Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, K562 Cells, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Pacific Ocean, Peptides, Cyclic chemistry, Peptides, Cyclic pharmacology, Stereoisomerism, Tumor Cells, Cultured drug effects, Actinomycetales chemistry, Antineoplastic Agents isolation & purification, Peptides, Cyclic isolation & purification
- Abstract
A new cyclic tetrapeptide (1) was isolated from the culture broth of an actinomycete of the genus Nocardiopsis collected from the Pacific deep-sea sediment. The structure of this compound was determined to be cyclo-(L-isoleucyl-L-prolyl-L-leucyl-L-prolyl) on the basis of combined chemical and spectral methods.
- Published
- 2003
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