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Objective: This study aimed to evaluate the surgical outcomes of 24 patients with lumbar spinal stenosis (LSS) treated by full-endoscopic interlaminar bilateral decompression using a unilateral approach. Materials and Methods: Twenty-four patients (seven males and 17 females) treated for LSS by the senior author and followed up for 18 months were included in the study. The pre-operative and postoperative clinical statuses were assessed using a neurological examination, a visual analog scale (VAS) score, and the Oswestry disability index (ODI). Preoperative lumbar magnetic resonance imaging, computed tomography (CT), and postoperative lumbar CT were performed. Results: Eight patients had isolated lateral recess stenosis, six had central lumbar stenosis, and 10 had both. A total of 31 spinal levels were treated using full endoscopic percutaneous interlaminar decompression. In patients undergoing a single-level procedure, the pre-operative mean VAS score was 9 and the postoperative mean VAS score was 2.5. The mean ODI was 43.5 before surgery and decreased to 11 after surgery. In patients with multi-level intervention, the mean VAS score was 8.5 and the mean ODI was 40 before surgery. Postoperatively, both decreased to 3.5 and 14.5, respectively. All pre- and postoperative values were significantly different. Conclusion: Full-endoscopic interlaminar bilateral decompression using a unilateral approach provided adequate decompression in selected patients. It also prevents unnecessary surgical trauma and tissue damage and enables better preservation of spine stability, even in patients operated on at multiple spinal levels. [ABSTRACT FROM AUTHOR]