1. COPD and occupational exposures: a case-control study.
- Author
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Weinmann S, Vollmer WM, Breen V, Heumann M, Hnizdo E, Villnave J, Doney B, Graziani M, McBurnie MA, and Buist AS
- Subjects
- Aged, Air Pollutants, Occupational analysis, Algorithms, Case-Control Studies, Dust analysis, Female, Health Maintenance Organizations, Humans, Interviews as Topic, Logistic Models, Male, Middle Aged, Occupational Exposure analysis, Occupational Exposure prevention & control, Oregon epidemiology, Pulmonary Disease, Chronic Obstructive prevention & control, Respiratory Protective Devices, Smoking epidemiology, Spirometry, Air Pollutants, Occupational adverse effects, Occupational Exposure adverse effects, Pulmonary Disease, Chronic Obstructive chemically induced, Pulmonary Disease, Chronic Obstructive epidemiology
- Abstract
Objective: Evidence demonstrates that occupational exposures are causally linked with chronic obstructive pulmonary disease (COPD). This case-control study evaluated the association between occupational exposures and prevalent COPD based on lifetime occupational history., Methods: Cases (n = 388) aged 45 years and older with COPD were compared with controls (n = 356), frequency matched on age, sex, and cigarette smoking history. Odds ratios for exposure to each of eight occupational hazard categories and three composite measures of exposure were computed using logistic regression. RESULTSOccupational exposures most strongly associated with COPD were diesel exhaust, irritant gases and vapors, mineral dust, and metal dust. The composite measures describing aggregate exposure to gases, vapors, solvents, or sensitizers (GVSS) and aggregate exposure to dust, GVSS, or diesel exhaust were also associated with COPD. In the small group of never-smokers, a similar pattern was evident., Conclusion: These population-based findings add to the literature linking occupational exposures to COPD.
- Published
- 2008
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