1. New Delhi metallo-β-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection.
- Author
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Kus JV, Tadros M, Simor A, Low DE, McGeer AJ, Willey BM, Larocque C, Pike K, Edwards IA, Dedier H, Melano R, Boyd DA, Mulvey MR, Louie L, Okeahialam C, Bayley M, Whitehead C, Richardson D, Carr L, Jinnah F, and Poutanen SM
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Male, Morganella morganii enzymology, Ontario, Polymerase Chain Reaction, Proteus mirabilis enzymology, Urine microbiology, beta-Lactam Resistance, beta-Lactamases genetics, Morganella morganii isolation & purification, Proteus mirabilis isolation & purification, beta-Lactamases urine
- Abstract
New Delhi metallo-β-lactamase-1 (NDM-1) is a recently identified metallo-β-lactamase that confers resistance to carbapenems and all other β-lactam antibiotics, with the exception of aztreonam. NDM-1 is also associated with resistance to many other classes of antibiotics. The enzyme was first identified in organisms isolated from a patient in Sweden who had previously received medical treatment in India, but it is now recognized as endemic throughout India and Pakistan and has spread worldwide. The gene encoding NDM-1 has been found predominantly in Escherichia coli and Klebsiella pneumoniae. We describe the isolation NDM-1-producing organisms from two patients in Toronto, Ontario. To the best of our knowledge, this is the first report of an organism producing NDM-1 that was locally acquired in Canada. We also discuss the evidence that NDM-1 can affect bacterial species other than E. coli and K. pneumoniae, the limited options for treatment and the difficulty laboratories face in detecting organisms that produce NDM-1.
- Published
- 2011
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