1. Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.
- Author
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Shibata N, Kawarai T, Lee JH, Lee HS, Shibata E, Sato C, Liang Y, Duara R, Mayeux RP, St George-Hyslop PH, and Rogaeva E
- Subjects
- ATP Binding Cassette Transporter 1, Aged, Caribbean Region epidemiology, Cholesterol 24-Hydroxylase, Female, Florida epidemiology, Genetic Predisposition to Disease epidemiology, Genetic Predisposition to Disease genetics, Hispanic or Latino statistics & numerical data, Humans, Male, Ontario epidemiology, Phenotype, Prevalence, Risk Factors, Statistics as Topic, ATP-Binding Cassette Transporters genetics, Alzheimer Disease genetics, Alzheimer Disease metabolism, Cholesterol metabolism, Risk Assessment methods, Steroid Hydroxylases genetics
- Abstract
Recent studies have demonstrated that cholesterol metabolism has an important role in Alzheimer's disease (AD) pathogenesis, suggesting that cholesterol-related genes may be significant genetic risk factors for AD. Based on the results of genome-wide screens, along with biological studies, we selected three genes as candidates for AD risk factors: ATP-binding cassette transporter A1 (ABCA1), cholesterol 25-hydroxylase (CH25H) and cholesterol 24-hydroxylase (CH24H). Case-control of North American Caucasians and AD families of Caribbean Hispanic origin were examined. Although excellent biological candidates, the case-control dataset did not support the hypothesis that these three genes were associated with susceptibility to AD. Similarly, no association was found in the Caribbean Hispanic families for CH25H. However, we did observe a possible interaction between ABCA1 and APOE in the Hispanics.
- Published
- 2006
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