1. Short, Enantioselective Total Synthesis of Chatancin.
- Author
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Zhao, Yu ‐ Ming and Maimone, Thomas J.
- Subjects
- *
ENANTIOSELECTIVE catalysis , *X-ray crystallography , *CRYSTAL structure , *NATURAL products - Abstract
An enantioselective total synthesis of the polycyclic diterpene (+)-chatancin, a potent PAF antagonist, is reported. Proceeding in seven steps from dihydrofarnesal, this synthetic route was designed to circumvent macrocyclization-based strategies to complex, cyclized cembranoids. The described synthesis requires only six chromatographic purifications, is high yielding, and avoids protecting-group manipulations. An X-ray crystal structure of this fragile marine natural product was obtained. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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