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1. Feasibility of low-dose interleukin-2 therapy following T-cell-depleted nonmyeloablative allogeneic hematopoietic stem cell transplantation from HLA-matched or -mismatched family member donors.

Author

Rizzieri DA, Crout C, Storms R, Golob J, Long GD, Gasparetto C, Sullivan KM, Horwitz M, Chute J, Lagoo AS, Morris A, Beaven A, Yang Y, Peterson B, Li Z, and Chao NJ

Subjects
Adult, Aged, Antineoplastic Agents adverse effects, Chemotherapy, Adjuvant, Drug Administration Schedule, Family, Fatigue etiology, Feasibility Studies, Graft vs Host Disease immunology, Humans, Immunosuppressive Agents therapeutic use, Interleukin-2 adverse effects, Middle Aged, Myelodysplastic Syndromes immunology, Neoplasms immunology, North Carolina, Pilot Projects, Time Factors, Transplantation Conditioning, Transplantation, Homologous, Treatment Outcome, Antineoplastic Agents administration & dosage, HLA Antigens immunology, Hematopoietic Stem Cell Transplantation adverse effects, Histocompatibility, Interleukin-2 administration & dosage, Myelodysplastic Syndromes therapy, Neoplasms therapy, Tissue Donors
Abstract

Introduction: High relapse rates and infections remain primary causes of failure in nonmyeloablative transplantation. Interleukin-2 (IL-2) may stimulate the immune system and improve outcomes. The primary objective of this pilot study was to evaluate the feasibility of administering IL-2 following a T-cell-depleted nonmyeloablative hematopoietic stem cell transplant., Methods: Patients received T-cell-depleted nonmyeloablative transplant from a matched or mismatched related donor. Those with allogeneic engraftment,

Published
2011
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