1. Antiviral Potential of Exogenous Human Omega Interferon to Inhibit Pandemic 2009 A (H1N1) Influenza Virus.
- Author
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Chun'e Xu, Xiaohong Song, Ling Fu, Dayong Dong, Shipo Wu, Guanlin Li, Shaoqiong Yi, Ting Yu, Rui Yu, Lihua Hou, and Wei Chen
- Subjects
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ANTIVIRAL agents , *DRUG synergism , *INTERFERONS , *DNA topoisomerase I , *PANDEMICS , *H1N1 influenza - Abstract
AbstractThe pandemic 2009 H1N1 influenza virus broke out in North America and spread rapidly throughout the world. The type I interferon (IFN) response represents one of the first lines of defense against influenza virus infections. In this study, the protective potential of human exogenous IFN-ω against pandemic 2009 A (H1N1) influenza virus was assessed both in vitroand in guinea pigs. The viral loads of pandemic 2009 A (H1N1) influenza virus strains A/California/04/2009 and A/Beijing/501/2009 were reduced by up to 5000-fold in Caco-2 cells by the addition of human IFN-ω. With daily intranasal treatment with human IFN-ω the viral load of pandemic 2009 A (H1N1) influenza virus strain A/California/04/2009 decreased by 1000-fold in lung tissues of guinea pigs. These results provide strong support for the application of human IFN-ω pretreatment to human influenza control. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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