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Objective: To describe differences between North America and Europe in the perioperative management of patients undergoing surgical aortic valve replacement (SAVR)., Methods: Patients with moderate or greater aortic stenosis or regurgitation requiring SAVR were enrolled in a prospective observational cohort evaluating the safety and efficacy of a new stented bioprosthesis at 25 centres in North America (Canada and the USA) and 13 centres in Europe (Germany, the Netherlands, France, the UK, Switzerland and Italy). While all patients underwent implantation with the same bioprosthetic model, perioperative management was left to the discretion of participating centres. Perioperative care was described in detail including outcomes up to 1-year follow-up., Results: Among 1118 patients, 643 (58%) were implanted in North America, and 475 (42%) were implanted in Europe. Patients in Europe were older, had a lower body mass index, less bicuspid disease and worse degree of aortic stenosis at baseline. In Europe, anticoagulant therapy at discharge was more aggressive, whereas length of stay was longer, and discharges directly to home were less common. Rehospitalisation risk was lower in Europe at 30 days (8.5% vs 15.9%) but converged at 1-year follow-up (26.5% vs 28.1%). Within continents, there were major differences between individual countries concerning perioperative management., Conclusion: Contemporary perioperative management of SAVR patients varies between North America and Europe in patient selection, procedural techniques, antithrombotic regimen and discharge management. Furthermore, rehospitalisation differed largely between continents and countries. Hence, geographical setting must be considered during design and interpretation of trials on SAVR., Trial Registration Number: NCT02088554., Competing Interests: Competing interests: BJJV: institutional research grant and speaker’s honorarium paid to his department by Medtronic. MDV: institutional research grant and reimbursement of travel expenses from Medtronic. VR: consultant to Medtronic, Gore and Abbott; advisory board, Medtronic. MJR: consultant to Medtronic, Abbott Medical, Boston Scientific, Gore Medical and Transverse Medical; fees paid to department. MWAC: speaker’s honoraria from Medtronic, Edwards Lifesciences, Terumo Aortic, Abbott Vascular and Cryolife. JFS: North American Principal Investigator of the PERIGON Pivotal Trial for Medtronic. FL: employee of Medtronic. RJMK: research support, consultation fees, and European Principal Investigator of the PERIGON Pivotal Trial for Medtronic., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)