1. A novel DRB1*04 allele.
- Author
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Endres RO, Wetzsteon PJ, Stein J, and Norman DJ
- Subjects
- Amino Acid Substitution, Base Sequence, Child, Codon, DNA Primers, Exons, HLA-DRB1 Chains, Haplotypes, Histocompatibility Testing, Humans, Kidney Transplantation, Middle Aged, Molecular Sequence Data, North America, Sequence Analysis, DNA, Tyrosine metabolism, White People genetics, Alleles, HLA-DR Antigens genetics
- Abstract
Discovery of the novel DRB1*0464 allele is described. This allele contains a nucleotide substitution in codon 13 that changes the amino acid histidine coded for in all other DRB1*04 alleles to tyrosine. This allele was found in a parent and one child of a North American Caucasian family with the haplotype: A*03, B*07, DRB1*0464, DRB4*0103, DQB1*0301.
- Published
- 2007
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