1. BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups.
- Author
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Xiromerisiou G, Hadjigeorgiou GM, Eerola J, Fernandez HH, Tsimourtou V, Mandel R, Hellström O, Gwinn-Hardy K, Okun MS, Tienari PJ, and Singleton AB
- Subjects
- Aged, Brain metabolism, Brain physiopathology, Brain Chemistry genetics, Cohort Studies, DNA Mutational Analysis, Female, Finland epidemiology, Gene Frequency, Genetic Markers genetics, Genetic Testing, Genetic Variation genetics, Genotype, Greece epidemiology, Humans, Male, Middle Aged, North America epidemiology, Parkinson Disease metabolism, White People genetics, Brain-Derived Neurotrophic Factor genetics, Genetic Predisposition to Disease genetics, Haplotypes genetics, Parkinson Disease ethnology, Parkinson Disease genetics, Polymorphism, Genetic genetics
- Abstract
Experimental and clinical data suggest that genetic variations in brain-derived neurotrophic factor (BDNF) gene may affect risk for Parkinson's disease (PD). We performed a case-control association analysis of BDNF in three independent Caucasian cohorts (Greek, North American, and Finnish) of PD using eight tagging SNPs and five constructed haplotypes. No statistically significant differences in genotype and allele frequencies were found between cases and controls in all series. A relatively rare BDNF haplotype showed a trend towards association in the Greek (p=0.02) and the Finnish (p=0.03) series (this haplotype was not detected in the North American series). However, given the large number of comparisons these associations are considered non-significant. In conclusion, our results do not provide statistically significant evidence that common genetic variability in BDNF would associate with the risk for PD in the Caucasian populations studied here.
- Published
- 2007
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