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Complex traits often exhibit complex underlying genetic architectures resulting from a combination of evolution from standing variation, hard and soft sweeps, and alleles of varying effect size. Increasingly, studies implicate both large‐effect loci and polygenic patterns underpinning adaptation, but the extent that common genetic architectures are utilized during repeated adaptation is not well understood. Sea age or age at maturation represents a significant life history trait in Atlantic Salmon (Salmo salar), the genetic basis of which has been studied extensively in European Atlantic populations, with repeated identification of large‐effect loci. However, the genetic basis of sea age within North American Atlantic Salmon populations remains unclear, as does the potential for a parallel trans‐Atlantic genomic basis to sea age. Here, we used a large single‐nucleotide polymorphism (SNP) array and low‐coverage whole‐genome resequencing to explore the genomic basis of sea age variation in North American Atlantic Salmon. We found significant associations at the gene and SNP level with a large‐effect locus (vgll3) previously identified in European populations, indicating genetic parallelism, but found that this pattern varied based on both sex and geographic region. We also identified nonrepeated sets of highly predictive loci associated with sea age among populations and sexes within North America, indicating polygenicity and low rates of genomic parallelism. Despite low genome‐wide parallelism, we uncovered a set of conserved molecular pathways associated with sea age that were consistently enriched among comparisons, including calcium signaling, MapK signaling, focal adhesion, and phosphatidylinositol signaling. Together, our results indicate parallelism of the molecular basis of sea age in North American Atlantic Salmon across large‐effect genes and molecular pathways despite population‐specific patterns of polygenicity. These findings reveal roles for both contingency and repeated adaptation at the molecular level in the evolution of life history variation. [ABSTRACT FROM AUTHOR]

The Hydrometeorological Sandbox - École de technologie supérieure (HYSETS) is a rich, comprehensive and large-scale database for hydrological modelling covering 14425 watersheds in North America. The database includes data covering the period 1950–2018 depending on the type and source of data. The data include a wide array of hydrometeorological data required to perform hydrological and climate change impact studies: (1) watershed properties including boundaries, area, elevation slope, land use and other physiographic information; (2) hydrometric gauging station discharge time-series; (3) precipitation, maximum and minimum daily air temperature time-series from weather station records and from (4) the SCDNA infilled gauge meteorological dataset; (5) the NRCan and Livneh gridded interpolated products' meteorological data; (6) ERA5 and ERA5-Land reanalysis data; and (7) the SNODAS and ERA5-Land snow water equivalent estimates. All data have been processed and averaged at the watershed scale, and provides a solid basis for hydrological modelling, climate change impact studies, model calibration assessment, regionalization method evaluation and essentially any study requiring access to large amounts of spatiotemporally varied hydrometeorological data. Measurement(s) elevation • temperature • hydrological precipitation process • Fluid Discharge • climate • physiographic feature Technology Type(s) digital curation Sample Characteristic - Environment watershed Sample Characteristic - Location North America Machine-accessible metadata file describing the reported data: 10.6084/m9.figshare.12600281 [ABSTRACT FROM AUTHOR]

We discuss a simple methodology to enable a statistical comparison of human population with the vegetation of North America over the past 13,000 years. Nonparametric kernel methods are applied for temporal and spatial smoothing of point data obtained from the Neotoma Paleoecology Database and the Canadian Archaeological Radiocarbon Database, which results in sequences of maps showing the development of population and different plant taxa during the Holocene. The estimation of smooth spatial and spatio‐temporal cross‐correlation functions is proposed in order to detect relationships between population and vegetation in fixed time intervals. Furthermore, the effects of varying environment on demographic changes as well as potential impacts of populations on plant taxa over time are analyzed. Pointwise confidence bands for cross‐correlation functions are computed and a robustness analysis is performed to assess the significance of obtained results. Considering the example of oak, an interpretation of our results for eastern North America shows the value of this methodology. [ABSTRACT FROM AUTHOR]

A major challenge in understanding the response of populations to climate change is to separate the effects of local drivers acting independently on specific populations, from the effects of global drivers that impact multiple populations simultaneously and thereby synchronize their dynamics. We investigated the environmental drivers and the demographic mechanisms of the widespread decline in marine survival rates of Atlantic salmon (Salmo salar) over the last four decades. We developed a hierarchical Bayesian life cycle model to quantify the spatial synchrony in the marine survival of 13 large groups of populations (called stock units, SU) from two continental stock groups (CSG) in North America (NA) and Southern Europe (SE) over the period 1971–2014. We found strong coherence in the temporal variation in postsmolt marine survival among the 13 SU of NA and SE. A common North Atlantic trend explains 37% of the temporal variability of the survivals for the 13 SU and declines by a factor of 1.8 over the 1971–2014 time series. Synchrony in survival trends is stronger between SU within each CSG. The common trends at the scale of NA and SE capture 60% and 42% of the total variance of temporal variations, respectively. Temporal variations of the postsmolt survival are best explained by the temporal variations of sea surface temperature (SST, negative correlation) and net primary production indices (PP, positive correlation) encountered by salmon in common domains during their marine migration. Specifically, in the Labrador Sea/Grand Banks for populations from NA, 26% and 24% of variance is captured by SST and PP, respectively and in the Norwegian Sea for populations from SE, 21% and 12% of variance is captured by SST and PP, respectively. The findings support the hypothesis of a response of salmon populations to large climate‐induced changes in the North Atlantic simultaneously impacting populations from distant continental habitats. [ABSTRACT FROM AUTHOR]

Between the initial colonization of North America and the European settlement period, Indigenous American land use practices shaped North American landscapes and ecosystems, but a critical question is the extent of these impacts on the land, and how these influenced the distributions of the flora and fauna. The present study addresses this question by estimating the spatial correlation between continental-scale records of fossil pollen and archaeological radiocarbon data, and provides a detailed analysis of the spatiotemporal relationship between palaeo-populations and ten important North American pollen taxa. Maps of Indigenous American population density, based on the Canadian Archaeological Radiocarbon Database, are compared to maps of plant abundance as estimated by pollen records from the Neotoma Paleoecology Database, using nonparametric kernel estimators and cross-correlation techniques. Periods of high spatial cross-correlation (either positive or negative) between population density and plant abundance were identified, but these associations were intermittent and did not increase towards the present. In many cases, high values of population density corresponded with high values of a particular taxon in one region, but simultaneously corresponded with low values in other regions, lessening the overall correlation between the two fields. This analysis suggests that human impacts were not significant enough to be identified at a continental scale, either due to low population numbers or land use, implying significant impacts of ancient human activities on the vegetation were regional rather than continental. [ABSTRACT FROM AUTHOR]

The West Greenland Atlantic Salmon (Salmo salar) fishery represents the largest remaining mixed-stock fishery for Atlantic Salmon in the Northwest Atlantic and targets multi-sea-winter (MSW) salmon from throughout North America and Europe. We evaluated stock composition of salmon harvested in the waters off West Greenland (n = 5684 individuals) using genetic mixture analysis and individual assignment to inform conservation of North American populations, many of which are failing to meet management targets. Regional contributions to this fishery were estimated using 2169 individuals sampled throughout the fishery between 2011 and 2014. Of these,22% were identified as European in origin. Major North American contributions were detected from Labrador (20%), the Southern Gulf/Cape Breton (29%), and the Gaspe Peninsula (29%). Minor contributions (5%) were detected from Newfoundland, Ungava, and Quebec regions. Region-specific catches were extrapolated using estimates of composition and fishery catch logs and harvests ranged from 300 to 600 and 2000 to 3000 individuals for minor and major constituents, respectively. To evaluate the temporal stability of the observed fishery composition, we extended the temporal coverage through the inclusion of previously published data (1995-2006, n = 3095) and data from archived scales (1968-1998, n = 420). Examination of the complete time-series (47 years) suggests relative stability in stock proportions since the late 1980s. Genetic estimates of stock composition were significantly associated with model-based estimates of returning MSW salmon (individual years r = 0.69, and overall mean r = 0.96). This work demonstrates that the analysis of both contemporary and archived samples in a mixed-stock context can disentangle levels of regional exploitation and directly inform assessment and conservation of Atlantic Salmon in the West Greenland interceptory Atlantic Salmon fishery. [ABSTRACT FROM AUTHOR]

Anadromous Atlantic salmon ( Salmo salar) is a species of major conservation and management concern in North America, where population abundance has been declining over the past 30 years. Effective conservation actions require the delineation of conservation units to appropriately reflect the spatial scale of intraspecific variation and local adaptation. Towards this goal, we used the most comprehensive genetic and genomic database for Atlantic salmon to date, covering the entire North American range of the species. The database included microsatellite data from 9142 individuals from 149 sampling locations and data from a medium-density SNP array providing genotypes for >3000 SNPs for 50 sampling locations. We used neutral and putatively selected loci to integrate adaptive information in the definition of conservation units. Bayesian clustering with the microsatellite data set and with neutral SNPs identified regional groupings largely consistent with previously published regional assessments. The use of outlier SNPs did not result in major differences in the regional groupings, suggesting that neutral markers can reflect the geographic scale of local adaptation despite not being under selection. We also performed assignment tests to compare power obtained from microsatellites, neutral SNPs and outlier SNPs. Using SNP data substantially improved power compared to microsatellites, and an assignment success of 97% to the population of origin and of 100% to the region of origin was achieved when all SNP loci were used. Using outlier SNPs only resulted in minor improvements to assignment success to the population of origin but improved regional assignment. We discuss the implications of these new genetic resources for the conservation and management of Atlantic salmon in North America. [ABSTRACT FROM AUTHOR]

Mortality and morbidity rates related to prescription opioid analgesics have been rising in North America and may be a gateway to the nonmedical use of prescription opioids (NUPO). The purpose of this study was to explore correlates of NUPO in the adolescent population given the scarce literature in this area. Cross-sectional data from 10,163 middle- and high-school students (15.1 ± 1.8 years old; 57.0% female; 55.6% White ethnic background) in Ontario were derived from the 2017 Ontario Student Drug Use and Health Survey. Potential correlates of NUPO in the past year included sociodemographic, behavioral, parental, and school characteristics. Overall prevalence of NUPO was 10.7%. In the final multivariable model, NUPO was significantly associated with 8 of the 21 correlates examined. Students who used prescription opioids nonmedically were of black, South Asian, and "other" ethnic backgrounds (OR 2.83, OR 1.77, and OR 1.67, respectively); reported a lower subjective socioeconomic status (OR 0.92), lower parental support (OR 0.90), and lower academic performance (OR 0.86); met physical activity recommendations (OR 1.48); consumed energy drinks (OR 1.42); smoked tobacco cigarettes (OR 2.33); and used cannabis (OR 1.84). Findings from this study show a wide variety of correlates of NUPO among Canadian adolescents, and highlight the need for further research and the value in targeted prevention and multi-level intervention programs for NUPO in this population. [ABSTRACT FROM AUTHOR]