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Background: Low hemoglobin (Hb) and iron deficiency among child bearing females have been linked to decreased immune system function, impaired cognitive functioning and complications in pregnancy. Methods: A total of 106 blood samples from apparently healthy nulliparous female students were assayed for Hb and serum iron concentrations using the cyanmethemoglobin and bathophenanthroline methods, respectively, to evaluate changes that may occur in these parameters at different phases of the reproductive cycle. Results: The mean (SD) Hb values during the ovulatory, menstrual, and follicular phases were 13.27 (1.14) g/dL, 12.05 (1.31) g/dL, and 12.23 (1. 56) g/dL, respectively. The prevalence of anemia (Hb<12 g/dL) was reported among 21 (19.8%) subjects, and 31 subjects declined to complete their samples collection. The mean serum iron concentrations during the 3 phases were 92.98 (18.25) μg/dL, 79.90 (13.14) μg/dL and 70.85 (18.65) μg/dL, respectively. A total of 28 (26.4%) study participants showed iron deficiency (serum level, <65 μg/dL). These variations in the values of Hb and serum iron concentrations were statistically significant in the 3 phases. However, no significant difference was observed in Hb concentrations between the menstrual and follicular phases. Of interest, a positive correlation was observed between the hemoglobin and serum iron concentrations within the phases, with the exception of a few cases that showed negative correlations. Conclusion: Menstruation has been shown to be the major cause of anemia and iron deficiency in nulliparous women. A prophylactic dose of iron and folate supplements may be indicated for menstruating females to cushion the adverse effects of menstruation on ematologic status. [ABSTRACT FROM AUTHOR]