1. Controlled trial of combinations of hydroxocobalamin-cystine and riboflavine-cystine, in Nigerian ataxic neuropathy.
- Author
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Osuntokun BO, Langman MJ, Wilson J, Adeuja AO, and Aladetoyinbo
- Subjects
- Ataxia etiology, Cyanides poisoning, Deafness etiology, Evaluation Studies as Topic, Female, Humans, Male, Middle Aged, Nigeria, Optic Atrophy etiology, Peripheral Nervous System Diseases etiology, Placebos, Poisoning drug therapy, Riboflavin Deficiency complications, Riboflavin Deficiency drug therapy, Syndrome, Thiocyanates blood, Vitamin B 12 therapeutic use, Ataxia drug therapy, Cystine therapeutic use, Deafness drug therapy, Hydroxocobalamin therapeutic use, Optic Atrophy drug therapy, Peripheral Nervous System Diseases drug therapy, Riboflavin therapeutic use
- Abstract
Chronic cyanide intoxication of dietary origin and riboflavine deficiency are believed to be major aetiological factors in Nigerian tropical ataxic neuropathy. The results are presented of a double-blind controlled therapeutic trial of combinations of large doses of hydroxocobalamin and cystine as cyanide binding agents together with riboflavine or placebos in Nigerian patients suffering from the tropical ataxic neuropathy. No clinical benefit was demonstrable with any of the treatments.
- Published
- 1974
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