1. Continued Transmission of Zika Virus in Humans in West Africa, 1992-2016.
- Author
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Herrera, Bobby Brooke, Chang, Charlotte A., Hamel, Donald J., Mboup, Souleymane, Ndiaye, Daouda, Imade, Godwin, Okpokwu, Jonathan, Agbaji, Oche, Bei, Amy K., and Kanki, Phyllis J.
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ZIKA virus , *HUMAN beings , *SEROPREVALENCE , *PHYLOGENY , *IMMUNOGLOBULIN M , *HIV infection complications , *HIV infection epidemiology , *EPIDEMIOLOGICAL research , *MALARIA , *POLYMERASE chain reaction , *RESEARCH funding , *RNA , *VIRAL antibodies , *RETROSPECTIVE studies , *REVERSE transcriptase polymerase chain reaction , *DISEASE complications - Abstract
First identified in 1947 in Uganda, Zika virus (ZIKV) has remained largely unstudied until the recent outbreak in Latin America. This study aimed to measure the prevalence of ZIKV in febrile patients in Senegal and Nigeria in samples collected from 1992 to 2016. The seroprevalence of ZIKV was 6.2% based on ZIKV immunoglobulin M and negative for dengue reactivity. ZIKV envelope was amplified from 4 samples. Phylogenetic analysis showed that the ZIKVs belonged to the African lineage, grouping with either the Nigerian or MR766 sublineages. This study provides evidence that ZIKV has been silently circulating in West Africa for 2 decades. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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