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This study examined the trends in the prevalence of breast cancer in Ilorin, Kwara State, Nigeria. Breast cancer is an uncontrolled growth of breast cells, Cancer occurs as a result of mutations, or abnormal changes, in the genes responsible for regulating the growth of cells and keeping them healthy. The focus of this research work was to evaluate the factors affect analyze some factors responsible for the survival of Breast cancer patient in Nigeria. Furthermore, this study used a total number of two hundred and six (206) dataset collected from the records of women between the ages of =15 and >45 years in the University of Ilorin Teaching Hospital (UITH), Kwara State. The methodology employed are non-parametric Kaplan-Meier method as well as Log-Rank statistic and the semiparametric such as Cox proportional hazards regression model to analyze the data in order to determine the hazard ratios of the various covariates. The result obtained by the PHreg procedure indicated that stages of breast cancer, year of admission, and age of patients as factors influencing the outcome of breast cancer patient in Nigeria. [ABSTRACT FROM AUTHOR]

Aim of the study: Determination of pharmacological activity relevant to wound healing of Bridelia ferruginea leaf, a traditional medicine used to treat wounds in rural Nigeria. Materials and methods: Aqueous and ethanolic leaf extracts were tested against bacterial species of relevance to wound infections: Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The ethanolic extracts were assessed for their ability to stimulate the growth of human dermal fibroblasts (FS5) and protect against damage induced by hydrogen peroxide. Antioxidant activity was also assessed using the DPPH assay. Results: Both aqueous and ethanolic extracts had weak antibacterial activity (MIC>470μg/ml). A significant effect (p <0.001) on the growth of FS5 fibroblasts was observed only at a concentration of 5μg/ml (28% increase), above which the extracts appeared toxic to the cells. The ethanolic extract offered the highest protection against H2O2 damage to FS5 cells, comparable with catalase (82% at 250μg/ml). The DPPH assay revealed antioxidant activity of the ethanolic leaf extract with IC50 12.5±0.3μg/ml comparable to l-ascorbic acid (7.3±0.1μg/ml). Conclusion: The antibacterial, modest fibroblast stimulation activity and relatively strong antioxidant activity lend some support to the topical use of Bridelia ferruginea leaf for wound-healing in the traditional medicine of South-western Nigeria. [Copyright &y& Elsevier]