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The discovery of alternative implants with regenerative potential comparable to autologous cartilage continues to be encouraged because of the high donor site morbidity rate. This research tries to make an alternative implant that uses the concept of tissue engineering techniques in the form of endogenous regeneration by combining Decellularized Bovine Cartilage scaffold with Platelet-Rich Fibrin (BCPRF) which is implanted subcutaneously. The aim of this study was to compare the potential for chondroregeneration between BCPRF and autologous cartilage as assessed by chondrocyte cell formation, type 2 collagen thickness, and implant resorption rate in subcutaneous implantation. Using the research design method is a pretest-posttest control group design using New Zealand white rabbits. Forty eight experimental samples were divided into 2 groups which were treated with BCPRF and autologous cartilage implantation. Results were evaluated after 6 weeks. Evaluation was carried out on 39 samples. Microscopy showed better potential for autologous cartilage chondroregeneration than BCPRF with significant differences in the number of chondrocytes formed, the thickness of type 2 collagen (p=0.000), and the rate of implant resorption (p=0.000). In conclusion, the potential for chondroregeneration of autologous cartilage and BCPRF is significantly different in terms of the number of chondrocytes formed, the thickness of type 2 collagen, and the rate of implant resorption. [ABSTRACT FROM AUTHOR]

Background: The aim of this study is to investigate the histopathological effects of 2-octyl-cyanoacrylate used in facial plastic operations that are applied for the fixation of cartilage graft types and the graft stabilization effect. Methods: In the study, 16 New Zealand-type rabbits weighing between 2250 g and 2500 g, 3-4 months old, were used. Two groups were formed as the study and control groups. Those using 2-octyl-cyanoacrylate for cartilage graft fixation were defined as the study group. Those using suturing were defined as the control group. The operation was planned with cartilage grafts taken from the ears of each rabbit and the study group on the left of the sagittal suture and the control group on the right. Results: Acute inflammation findings were found in 19 (39.6%) of the study group and 6 (14%) of the control group. Acute inflammation levels were found to be higher in the study group than in the control group (P = .006). Mild inflammation was found in 20 (41.7%) of the study group, moderate inflammation in 7 (14.6%), and severe inflammation in 2 (4.2%). Mild inflammation was detected in 10 (23.3%) of the control group. Chronic inflammation levels were higher in the study group than in the control group. Foreign body reaction was detected in 28 (58.3%) of the study group and 14 (32.6%) of the control group. Foreign body reaction levels were found to be higher in the study group than in the control group. Conclusion: We think that the use of 2-octyl-cyanoacrylate in cartilage graft fixation is not correct as it may increase the risk of postoperative complications. [ABSTRACT FROM AUTHOR]