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Objective: The temporomandibular joint (TMJ) is anatomically comprised of the mandibular condylar cartilage (CC) lined with fibrocartilaginous superficial zone and is crucial for eating and dental occlusion. TMJ osteoarthritis (OA) leads to pain, joint dysfunction and permanent loss of cartilage tissue. However, there are no drugs clinically available that ameliorate OA and little is known about global profiles of genes that contribute to TMJ OA. Furthermore, animal models that recapitulate the complexity of signalling pathways contributing to OA pathogenesis are crucial for designing novel biologics that thwart OA progression. We have previously developed a New Zealand white rabbit TMJ injury model that demonstrates CC degeneration. Here, we performed genome‐wide profiling to identify new signalling pathways critical for cellular functions during OA pathology. Materials and Methods: Temporomandibular joint OA was surgically induced in New Zealand white rabbits. Three months following injury, we performed global gene expression profiling of the TMJ condyle. RNA samples from TMJ condyles were subjected to sequencing. After raw RNA‐seq data were mapped to relevant genomes, differential expression was analysed with DESeq2. Gene ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis were conducted. Results/Conclusions: Our study revealed multiple pathways altered during TMJ OA induction including the Wnt, Notch and PI3K‐Akt signalling pathways. We demonstrate an animal model that recapitulates the complexity of the cues and signals underlying TMJ OA pathogenesis, which is essential for developing and testing novel pharmacologic agents to treat OA. [ABSTRACT FROM AUTHOR]

• The compressive behaviour of square RACFSST stub columns after exposure to fire is investigated. • Twelve post-fire compression tests are conducted. • The influences of heating durations and RCA replacement ratios are discussed. • Thermal and mechanical FE models are validated against test results and then used to conduct parametric studies. • The relevant design codes are assessed against the test and FE data. Experimental and numerical studies on the cross-section compressive behaviour and residual resistances of square recycled aggregate concrete-filled stainless steel tube (RACFSST) stub columns after exposure to fire are reported in this paper. An experimental programme was firstly carried out on twelve stub column specimens with three recycled coarse aggregate replacement ratios (0%, 35% and 70%) after exposure to the ISO-834 standard fire for 0 min (i.e. at ambient temperature), 15 min, 30 min and 45 min. The test results, including load–end shortening curves, failure loads and failure modes, were presented, with the initial compressive stiffness and confinement effect analysed. The experimental programme was followed by a numerical modelling programme, where thermal and mechanical finite element models were developed and validated against the test results and afterwards used to conduct parametric studies to generate additional numerical data over a wide range of cross-section dimensions. Based on the test and numerical data, the relevant design rules for square natural aggregate concrete-filled carbon steel tube stub columns at ambient temperature, as specified in the European code, Australia/New Zealand standard and American specification, were evaluated, using post-fire material properties, for their applicability to square RACFSST stub columns after exposure to fire. The evaluation results generally revealed that the European code and Australian/New Zealand standard led to a good level of design accuracy, while the American specification resulted in slightly conservative post-fire cross-section compression resistance predictions. [ABSTRACT FROM AUTHOR]

This paper presents experimental and numerical investigations into the post-fire cross-section compressive behaviour and resistances of circular recycled aggregate concrete-filled stainless steel tube (RACFSST) stub columns. Twelve stub column specimens, fabricated from concretes with three recycled coarse aggregate replacement ratios (0%, 35% and 70%), were tested after exposure to the ISO-834 standard fire for 0 min (i.e. at ambient temperature), 15 min, 30 min and 45 min. The experimental investigation included heating and cooling of specimens, cylinder tests and post-fire tensile coupon tests and stub column tests. The test results, including load–end shortening curves, failure loads and failure modes, were fully reported and the initial compressive stiffnesses and confinement effect were discussed. The numerical investigation was subsequently conducted, where thermal and mechanical finite element models were developed and validated against the test results and then used to perform parametric studies to generate further numerical data. Given the absence of design codes for stainless steel–recycled aggregate concrete composite structures after exposure to fire, the relevant design rules for circular natural aggregate concrete-filled carbon steel tube stub columns at ambient temperature, as set out in the European code, Australia/New Zealand standard and American specification, were assessed, using post-fire material properties, for their applicability to circular RACFSST stub columns after exposure to fire, based on the test and numerical data. The assessment results generally revealed that the European code and the Australian/New Zealand standard led to an acceptable level of design accuracy and consistency, while the American specification resulted in rather conservative and scattered post-fire cross-section compression resistance predictions. • The compressive behaviour of circular RACFSST stub columns after exposure to fire is investigated. • Post-fire compression tests on twelve circular RACFSST stub column specimens are conducted. • The influences of heating durations and RCA replacement ratios are analysed. • Thermal and mechanical FE models are validated against test results and then used to conduct parametric studies. • The relevant design codes are assessed against the test and FE data. [ABSTRACT FROM AUTHOR]