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This study investigates the simultaneous effect of substrate nanostructuring by severe plastic deformation and surface modification by SLActive on surface characteristics of CP-Ti grade 2 and evaluates the biocompatibility of it for use as implant material by in-vivo test. SLActive surface modification method is a modified SLA process that includes sandblasting, acid-etching, and cleaning by N 2 in a vacuum chamber. To this end, the structure CP-Ti grade 2 was refined by applying the equal channel angular pressing (ECAP) method. Surface morphology, roughness, and wettability of coarse-grained (CG) and ultrafine-grained (UFG) CP-Ti and Ti-6Al-4V were determined after SLActive. It was seen that after surface modification of the samples by SLActive, the excellent wettability with a drop contact angle of about 0° was achieved for SLActived specimens. For the in-vivo test, the implants of each three groups were embedded in the femur of white New Zealand rabbits. In order to assess the osseointegration of implants, histological analysis, and pull-out tests were conducted. Results showed suitable osseointegration between implant and bone for every three groups, but the value of removal torque was higher for UFG-Ti. As is realized UFG-Ti sample surface modified by SLActive could be a suitable choice among the candidates to be used as a material in the manufacturing of dental implants. [ABSTRACT FROM AUTHOR]