1. Interferon γ and interleukin 10 responses in immunocompetent and immunosuppressed New Zealand White rabbits naturally infected with Encephalitozoon cuniculi.
- Author
-
Rodríguez-Tovar, Luis E., Castillo-Velázquez, Uziel, Arce-Mendoza, Alma Y., Nevárez-Garza, Alicia M., Zarate-Ramos, Juan J., Hernández-Vidal, Gustavo, Rodríguez-Ramírez, Heidi G., and Trejo-Chávez, Armando
- Subjects
- *
INTERFERONS , *INTERLEUKIN-10 , *IMMUNOCOMPETENT cells , *NOSEMA cuniculi , *GLUCOCORTICOIDS , *ANIMAL models in research , *IMMUNOSUPPRESSION - Abstract
Levels of interferon (IFN)-γ and interleukin (IL)-10 were measured in the serum of immunocompetent and immunosuppressed New Zealand White rabbits naturally infected with Encephalitozoon cuniculi . IFN-γ levels were elevated in infected rabbits, and a synergic effect was observed in animals treated with the immunosuppressive agent dexamethasone (Dex). The role of IL-10 in infected rabbits remains unclear, as IL-10 levels were similar to those of negative controls. Dex appeared to exhibit a proinflammatory effect, as IFN-γ levels were elevated in infected immunosuppressed rabbits. Similarly, Dex exhibited a synergic effect in infected immunosuppressed rabbits, as evidenced by the elevation in IFN-γ production. These data indicate that the immune response to this glucocorticoid should be considered in the design of future animal model studies of immunosuppression. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF