1. Multisystem inflammatory syndrome in children related to COVID-19: A New York City experience.
- Author
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Riollano-Cruz M, Akkoyun E, Briceno-Brito E, Kowalsky S, Reed J, Posada R, Sordillo EM, Tosi M, Trachtman R, and Paniz-Mondolfi A
- Subjects
- Adolescent, COVID-19 epidemiology, COVID-19 immunology, Child, Child, Preschool, Female, Humans, Male, New York City epidemiology, Retrospective Studies, Tertiary Care Centers, Young Adult, COVID-19 complications, Cytokines immunology, Systemic Inflammatory Response Syndrome epidemiology
- Abstract
In December 2019, the 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as a low risk for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic inflammatory disease, with features that overlap with Kawasaki disease (KD). We describe the first 15 cases with the multi-systeminflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease among Hispanic/Latino and Black/African American ancestry, the distinct cytokine signature across the disease spectrum (IL-1/IL-6), and the potential role and pathogenesis of SARS-CoV-2 in this new clinical entity., (© 2020 Wiley Periodicals LLC.)
- Published
- 2021
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