1. Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York: epidemiology and recommendations for detection.
- Author
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Bratu S, Mooty M, Nichani S, Landman D, Gullans C, Pettinato B, Karumudi U, Tolaney P, and Quale J
- Subjects
- Health Planning Guidelines, Humans, Klebsiella Infections microbiology, Klebsiella pneumoniae enzymology, Klebsiella pneumoniae genetics, Laboratories standards, Microbial Sensitivity Tests methods, Microbial Sensitivity Tests standards, Microbiology, New York City epidemiology, beta-Lactam Resistance, beta-Lactamases genetics, Anti-Bacterial Agents pharmacology, Carbapenems pharmacology, Klebsiella Infections epidemiology, Klebsiella pneumoniae drug effects, beta-Lactamases metabolism
- Abstract
Among 257 isolates of Klebsiella pneumoniae collected in Brooklyn, NY, 24% were found to possess bla(KPC). Clinical microbiology laboratories that used automated broth microdilution systems reported 15% of the KPC-possessing isolates as susceptible to imipenem. The imipenem MIC was found to be markedly affected by the inoculum. For accurate detection of KPC-possessing K. pneumoniae, particular attention should be paid to proper inoculum preparation for broth-based susceptibility methods. In addition, using ertapenem or meropenem for class reporting of carbapenem susceptibility will improve detection.
- Published
- 2005
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