1. Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories.
- Author
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Dhamoon MS, Cheung YK, Moon YP, Wright CB, Sacco RL, and Elkind MSV
- Subjects
- Activities of Daily Living, Adult, Aged, Aged, 80 and over, Biomarkers blood, Cohort Studies, Disabled Persons, Female, Humans, Inflammation Mediators blood, Male, Middle Aged, Myocardial Infarction blood, New York City, Prospective Studies, Risk Factors, Stroke blood, 1-Alkyl-2-acetylglycerophosphocholine Esterase blood, Interleukin-6 blood, Physical Functional Performance
- Abstract
Background/objectives: Inflammatory biomarkers have been associated with stroke and mortality, but inflammation may also have detrimental effects beyond acute events. We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely associated with long-term functional decline independently of vascular risk factors, stroke and myocardial infarction (MI) occurring during follow-up., Design: Prospective population based cohort study., Setting: The Northern Manhattan Study., Participants (including the Sample Size): Race/ethnically diverse stroke-free individuals in northern Manhattan aged ≥40 years (n = 3298)., Intervention: None., Measurements: Annual functional assessments with the Barthel index (BI), for a median of 13 years. BI was analyzed as a continuous variable (range 0-100). Baseline demographics, risk factors, and laboratory studies were collected, including IL6 (n = 1679), LpPLA2 mass (n = 1912) and activity (n = 1937). Separate mixed models estimated standardized associations between each biomarker and baseline functional status and change over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression measured at baseline, and stroke and MI occurring during follow-up., Results: Mean age was 69 (SD 10) years, 35% were male, 53% Hispanic, 74% hypertensive, and 16-24% diabetic. LogIL6 was associated with decline in BI over time (-0.13 points per year, 95% CI -0.24, -0.02) and marginally with baseline BI (-0.20, 95% CI -0.40, 0.01). LpPLA2 activity levels were associated with baseline BI (-0.36, 95% CI -0.68, -0.04) but not change over time, and LpPLA2 mass levels were not associated with either., Conclusion: In this large population-based study, higher serum inflammatory biomarker levels were associated with disability, even when adjusting for baseline covariates and stroke and MI occurring during follow-up., Competing Interests: Dr. Sacco receives grant support from the NIH, AHA, and Boehringer Ingelheim. Dr. Elkind receives compensation for providing consultative services for Biotelemetry/Cardionet, BMSPfizer Partnership, Boehringer-Ingelheim, and Sanofi-Regeneron; serves as an expert witness for Merck/Organon (Nuvaring and stroke), BMS-Sanofi Partnership (Plavix and stroke), and Hi-Tech (DMAA and stroke); serves on the National, Founders Affiliate, and New York City chapter boards of the American Heart Association/American Stroke Association; and receives royalties from UpToDate for chapters related to cryptogenic stroke. There are no patents, products in development or marketed products associated with this research to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
- Published
- 2019
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