1. Detection of human T-lymphotropic virus (HTLV) tax sequences in New York City blood donors seronegative for HTLV types 1 and 2.
- Author
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Dezzutti CS, Guenthner PC, Daniel S, Utz U, Cabrera T, Marshall JH, Bianco C, Lal RB, and Cowan EP
- Subjects
- Adult, Antibody Specificity, Female, Gene Products, tax immunology, HTLV-I Antibodies immunology, HTLV-I Infections blood, HTLV-I Infections epidemiology, HTLV-II Antibodies immunology, HTLV-II Infections blood, HTLV-II Infections epidemiology, Human T-lymphotropic virus 1 genetics, Human T-lymphotropic virus 1 immunology, Human T-lymphotropic virus 2 genetics, Human T-lymphotropic virus 2 immunology, Humans, Immunoenzyme Techniques, Male, New York City epidemiology, Polymerase Chain Reaction, Prevalence, Risk Factors, Blood Donors, Genes, pX, HTLV-I Antibodies blood, HTLV-I Infections diagnosis, HTLV-II Antibodies blood, HTLV-II Infections diagnosis, Human T-lymphotropic virus 1 isolation & purification, Human T-lymphotropic virus 2 isolation & purification, Lymphocytes virology
- Abstract
A potential public health concern is the reported detection of the human T-lymphotropic virus (HTLV) tax gene in the lymphocytes of up to 11% of a low-risk group of New York City blood donors (NYBD). This study aimed to independently confirm the prevalence of HTLV tax sequences in 293 NYBD. All NYBD tested negative for antibodies to HTLV types 1 and 2 and HTLV Tax. HTLV tax sequences were not detected in the NYBD lymphocytes. These data demonstrate the lack of HTLV-1 tax in this group of NYBD at low risk for HTLV infection.
- Published
- 2003
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