1. High Response Rates to Neoadjuvant Chemotherapy in High-Grade Upper Tract Urothelial Carcinoma.
- Author
-
Meng X, Chao B, Vijay V, Silver H, Margolin EJ, Balar A, Taneja SS, Shah O, Bjurlin MA, Anderson CB, and Huang WC
- Subjects
- Aged, Carcinoma, Transitional Cell diagnosis, Carcinoma, Transitional Cell mortality, Chemotherapy, Adjuvant, Disease-Free Survival, Female, Follow-Up Studies, Humans, Male, Middle Aged, New York epidemiology, Retrospective Studies, Survival Rate trends, Treatment Outcome, Urologic Neoplasms diagnosis, Urologic Neoplasms mortality, Antineoplastic Agents therapeutic use, Carcinoma, Transitional Cell therapy, Neoplasm Staging, Nephroureterectomy methods, Urologic Neoplasms therapy
- Abstract
Objective: To evaluate the impact of cisplatin-based neoadjuvant chemotherapy (NAC) in patients who underwent nephroureterectomy for high-grade (HG) upper tract urothelial carcinoma (UTUC)., Methods: Retrospective review was conducted of patients with HG UTUC from 2011 to 2017 who underwent nephroureterectomy at 2 institutions. Patients with eGFR >50 mL/min/1.73 m
2 were considered eligible for NAC and were referred for evaluation of NAC prior to nephroureterectomy. Patient demographics, kidney function, clinical and pathologic response rates, and outcomes were analyzed., Results: Of 95 patients with HG UTUC meeting inclusion criteria (mean age 72.3 years, mean preop eGFR 57.0 mL/min/1.73 m2 ), 61 patients were considered eligible for NAC with eGFR >50 mL/min/1.73 m2 , of which 25 (41%) received NAC. Of the patients who received NAC, 80% (20/25) of the patients had clinical response on imaging and 80% (20/25) had pathologic response (- Published
- 2019
- Full Text
- View/download PDF