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Purpose: The purpose of the study was to examine the effect of a holistic program, the Collaborative Care Model (CCM) Program, and the development of a self-care plan on health-promoting behaviors in hospital nurses., Design: A quasi-experimental, pretest, posttest, repeated measure, comparison-group design was used., Method: The study was conducted in a large, academic medical center in the northeast. The experimental group included registered nurses (RNs) from units in one institution introduced to the CCM and development of a self-care plan in an 8-hour program. The control group received no intervention. Data were collected using the Health Promoting Lifestyle Profile II instrument (HPLP II); a 52-question Likert-type scale with six subscales examining health-promoting behaviors., Findings: Using repeated measures analysis of variance there was a significant increase (p = .02) in the overall HPLP II mean, spirituality ( p = .04), interpersonal relations (p = .04), and nutrition scores (p = .04) of the experimental group as compared over time with the control group., Conclusions: The CCM plus the development of a self-care plan significantly increased overall health promoting behaviors, and spirituality, interpersonal relations, and nutrition scores in these RNs.