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This case series describes the feasibility of orifice-assisted small-incision surgery (OASIS), a novel technique that may incorporate benefits of single-incision and natural-orifice surgery while minimizing issues such as instrument crowding and interaction of optical access with operative instrumentation. In our multiple-site series, we included patients from a large academic medical center in the northeastern United States and a private gynecology clinic in India. Between the 2 centers, a total of 14 patients (5 with benign disease and 9 with oncologic disease) underwent the following procedures: OASIS total laparoscopic hysterectomy, laparoscopic supracervical hysterectomy, laparoscopic myomectomy, or laparoscopic radical hysterectomy with pelvic lymph node dissection. The initial 14 cases were safely completed. Oncologic clearance was consistent with specialty norms. Operating time ranged from 60 to 150 minutes, and estimated blood loss ranged from 10 to 500 mL. Detailed procedure descriptions and videos are provided. Based on preliminary case series experience, OASIS seems to be a safe and feasible addition to the advanced minimally invasive surgeons' armamentarium for both benign and oncologic cases., (Copyright © 2012 AAGL. Published by Elsevier Inc. All rights reserved.)