1. Incidence of catheter-related thrombosis and its association with outcome in critically ill patients: A prospective observational study.
- Author
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Smit JM, Haaksma ME, Heldeweg MLA, Adamse DS, Choi KF, Jonker SRL, Rijpkema J, van Zanten FJL, Vlaar APJ, Müller MCA, Girbes ARJ, Heunks LMA, and Tuinman PR
- Subjects
- Humans, Male, Female, Middle Aged, Prospective Studies, Incidence, Aged, Thrombosis etiology, Thrombosis epidemiology, Catheterization, Central Venous adverse effects, Central Venous Catheters adverse effects, Intensive Care Units, Netherlands epidemiology, Catheter-Related Infections epidemiology, Catheter-Related Infections etiology, Pulmonary Embolism epidemiology, Pulmonary Embolism etiology, Pulmonary Embolism mortality, Risk Factors, Prevalence, Critical Illness
- Abstract
Background: Incidence of central venous catheter (CVC)-related thrombosis in critically ill patients remains ambiguous and its association with potential hazardous sequelae unknown. The primary aim of the study was to evaluate the epidemiology of CVC-related thrombosis; secondary aims were to assess the association of catheter-related thrombosis with catheter-related infection, pulmonary embolism and mortality., Methods: This was a single-center, prospective observational study conducted at a tertiary intensive care unit (ICU) in the Netherlands. The study population consisted of CVC placements in adult ICU patients with a minimal indwelling time of 48 h. CVC-related thrombosis was diagnosed with ultrasonography. Primary outcomes were prevalence and incidence, incidence was reported as the number of cases per 1000 indwelling days., Results: 173 CVCs in 147 patients were included. Median age of patients was 64.0 [IQR: 52.0, 72.0] and 71.1 % were male. Prevalence of thrombosis was 0.56 (95 % CI: 0.49, 0.63) and incidence per 1000 indwelling days was 65.7 (95 % CI: 59.0, 72.3). No association with catheter-related infection was found (p = 0.566). There was a significant association with pulmonary embolism (p = 0.022). All 173 CVCs were included in the survival analysis. Catheter-related thrombosis was associated with a lower 28-day mortality risk (hazard ratio: 0.39, 95 % CI: 0.17, 0.87)., Conclusion: In critically ill patients, prevalence and incidence of catheter-related thrombosis were high. Catheter-related thrombosis was not associated with catheter-related infections, but was associated with pulmonary embolism and a decreased mortality risk., Competing Interests: Declaration of competing interest The authors declare that they have no competing interests., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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