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Abstract: Objectives: Peripheral arterial disease (PAD) is associated with adverse cardiovascular events and can significantly impair patients'' health status. Recently, marked methodological improvements in the measurement of PAD patients'' health status have been made. The Peripheral Artery Questionnaire (PAQ) was specifically developed for this purpose. We validated a Dutch version of the PAQ in a large sample of PAD patients. Design: Cross-sectional study. Methods: The Dutch PAQ was completed by 465 PAD patients (70% men, mean age 65±10 years) participating in the Euro Heart Survey Programme. Principal components analysis and reliability analyses were performed. Convergent validity was documented by comparing the PAQ with EQ-5D scales. Results: Three factors were discerned; Physical Function, Perceived Disability, and Treatment Satisfaction (factor loadings between 0.50 and 0.90). Cronbach''s α values were excellent (mean α =0.94). Shared variance of the PAQ domains with EQ-5D scales ranged from 3 to 50%. Conclusions: The Dutch PAQ proved to have good measurement qualities; assessment of Physical Function, Perceived Disability, and Treatment Satisfaction facilitates the monitoring of patients'' perceived health in clinical research and practice. Measuring disease-specific health status in a reliable way becomes essential in times were a wide array of treatment options are available for PAD patients. [Copyright &y& Elsevier]