Competing Interests: Declaration of Competing Interest Dr. Maggi has received honoraria for speaking, advisory boards and compensation for congress participations from Sanofi Genzyme, Roche and Biogen, Amicus Therapeutics, Alexion, Janssen, Lupin, outside the submitted work. Dr. D'Amico has received honoraria as consultant in scientific advisory boards and for sponsored lectures form PTC therapeutics Roche, Avexis, Sanofi-Genzyme and Biogen outside the submitted work. Dr. Bonanno has received honoraria for speaking, advisory boards and compensation for congress participations from Biogen, Roche, Alexion and Sanofi Genzyme. Dr Andrés Nascimento has received honoraria for speaking, advisory boards and compensation for congress participations from Sanofi Genzyme, Roche, Sarepta, PTC therapeutics, Biogen, SRK, and Novartis.