1. Long-term clinical outcome of patients with soft tissue sarcomas treated with limb-sparing surgery and postoperative radiotherapy.
- Author
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Felderhof, Joeke M., Creutzberg, Carien L., Putter, Hein, Nout, Remi A., Bovée, Judith V. M. G., Dijkstra, P. D. Sander, Hartgrink, Henk H., and Marijnen, Corrie A. M.
- Subjects
CONFIDENCE intervals ,LEG ,HEALTH outcome assessment ,RADIOTHERAPY ,SARCOMA ,SCALES (Weighing instruments) ,SOFT tissue tumors ,SURVIVAL analysis (Biometry) ,DISEASE relapse ,TREATMENT effectiveness ,PROPORTIONAL hazards models ,DATA analysis software ,DESCRIPTIVE statistics ,KAPLAN-Meier estimator - Abstract
Background. To evaluate long-term local control, survival, radiation side effects and functional outcome after limb-sparing surgery followed by postoperative radiotherapy (RT) for soft tissue sarcoma (STS). Material and methods. Between 1995 and 2010, 118 patients with STS of an extremity were treated with limb-sparing surgery and postoperative RT. Follow-up was complete for all patients. Acute and late radiation related toxicities were scored using CTCAE v4.0. Results. Median follow-up was 93 months. RT dose was 60 Gy in 92.4% of the patients; 5.1% received 66 Gy; 2.5% 50-56 Gy. Actuarial local recurrence rates at five and 10 years were 9% and 12%. Five- and 10-year overall survival rates were 69% and 51%. Acute radiation toxicities occurred in 91% of the patients; 19% were grade 3, 2% grade 4. Late radiation toxicities were reported in 71% of the patients: 50% grade 1, 18% grade 2, and 3% grade 3. Limb and joint function after treatment were good, 19% having mild limitation of motion, 1.5% moderate, and 2.5% severe limitations. Conclusion. Limb-sparing surgery with 60 Gy postoperative radiotherapy for patients with STS provides excellent local control and high survival rates with acceptable toxicity and functional outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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