1. Association of pesticide exposure, vaccination response, and interleukin-1 gene polymorphisms.
- Author
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Baranska M, Van Amelsvoort L, Birindelli S, Fustinoni S, Corsini E, Liesivuori J, and Van Loveren H
- Subjects
- Alleles, Bulgaria, Cross-Sectional Studies, Finland, Gene Frequency, Genotype, Hepatitis B Vaccines immunology, Humans, Immune System immunology, Immune System physiopathology, Immunity drug effects, Immunity immunology, Interleukin 1 Receptor Antagonist Protein genetics, Interleukin-1alpha genetics, Interleukin-1beta genetics, Italy, Netherlands, Occupational Exposure adverse effects, Occupational Exposure prevention & control, Polymerase Chain Reaction, Risk Assessment, Vaccination, Immune System drug effects, Interleukin-1 genetics, Occupational Exposure analysis, Pesticides poisoning, Polymorphism, Genetic
- Abstract
We performed a cross-sectional study involving workers from four European countries in which exposure to pesticides and immune parameters were evaluated over a short period of time. The total study population consisted of 238 workers occupationally exposed to pesticides and 198 nonoccupationally exposed workers. The study showed that pesticide exposure at levels encountered by workers under different conditions in Europe did not affect the ability of the immune system to respond to vaccination. We could, however, identify individuals within the group of pesticide exposed workers who were genetically characterized by the 2.2 IL-1alpha polymorphism and who showed a lower antibody response, pointing out the importance of the understanding of genetic variability and the interaction between genetic and environmental factors in the identification of high-risk individuals, which may eventually lead to preventive measures.
- Published
- 2008
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