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Background: This study aimed to investigate the association between adolescents' adherence to attention‐deficit/hyperactivity disorder (ADHD) medication and their risk of committing minor offenses. Methods: Using two Dutch databases, Statistics Netherlands (CBS) and the Foundation for Pharmaceutical Statistics (SFK), we aimed to investigate the association between adherence to ADHD medication and registered minor offenses between 2005 and 2019 of 18,234 adolescents (12–18 years). We used Cox regression analyses to compare the rate of committing minor offenses of adolescents during periods of high ADHD medication adherence compared to periods of low adherence (i.e., periods with or without sufficient amounts of dispensed medication). We additionally tested associations with adherence to selective serotonin reuptake inhibitors (SSRIs) as control medication and analyzed potential reverse causation. Results: High ADHD medication adherence was associated with a reduced risk of committing a minor offense of between 33% and 38% compared to low adherence periods of ≥3 months (hazard ratio [HR] 0.67, confidence interval [CI] 0.64–0.71) or ≥6 months (HR 0.62, CI 0.59–0.65). The reduction in risk can likely be attributed to ADHD medication, given the absence of effects of SSRIs and no reverse causation. The reduction rate remained between 16% and 55% per sex, stimulant versus non‐stimulant medication, different offense categories and further sensitivity analyses. Conclusions: Among adolescents using ADHD medication, rates of criminality were lower during periods of high medication adherence, suggesting that adherence to ADHD medication may contribute to prevention of minor offenses in adolescents. [ABSTRACT FROM AUTHOR]

Consuming media entertainment often challenges recipients' self-control. While past research related self-control almost exclusively to whether individuals engage in media use, it might be equally relevant for the disengagement from media use. Testing core assumptions of the Appraisal of Media Use, Self-Control, and Entertainment (AMUSE) model, the present study investigates the situational interplay of self-control and affective appraisals in predicting disengagement from Netflix use. Preregistered hypotheses were tested based on an event-contingent experience sampling design, in which 205 adult Netflix users in the Netherlands and Germany were tracked and surveyed for two weeks. Results demonstrate that disengagement is contingent upon enjoyment and appreciation and that enjoyment, in turn, can be "spoiled" by feeling guilty. Self-control influenced goal conflict and enjoyment throughout the reception process. We discuss opportunities for modeling disengagement from media use with situational research approaches. [ABSTRACT FROM AUTHOR]

Objective: To investigate whether externalizing and internalizing problems are related to lower and higher heart rate (HR), respectively, and to explore the relationship of these problems with respiratory sinus arrhythmia (RSA) and baroreflex sensitivity (BRS). Moreover, to study whether problems present at both preschool and preadolescent age show stronger associations with autonomic function than those that were not. Method: In a population cohort of 10- to 13-year-old children (N = 931; 11.6 [+ or -] 0.5 years; 47% boys), autonomic measurements in supine and standing position were performed at school. RSA and BRS were determined by spectral analysis. Current externalizing and internalizing problems were assessed by the Child Behavior Checklist and problems at age 4 to 5 retrospectively by the Preschool Behavior Questionnaire. Results: At supine rest, current externalizing problems were associated with lower HR and higher RSA, but not with BRS and current internalizing problems with higher HR and lower RSA, but not with BRS. These results were specifically found in children with problems that were retrospectively reported to have been also present at preschool age. Standing-induced changes in autonomic parameters were unrelated to the behavioral dimensions. Conclusions: Externalizing and internalizing problems are associated with divergent autonomic patterns, suggesting autonomic underarousal and overarousal, respectively. Problems starting early in life may specifically account for this. This should be confirmed in prospective studies. (Contains 4 tables.)

Aims: Between 2008 and 2012, the number of children and adolescents in the Netherlands who received methylphenidate prescriptions increased by 35.6%. We determined guideline adherence regarding the assessment of attention-deficit/hyperactivity disorder (ADHD) and rates of off-label use in those 2 years. We also compared adherence to guidelines between mental health and pediatrics settings. Methods: We conducted a medical file audit of 506 children or adolescents who had received a first methylphenidate prescription in 2008 (n = 208) or 2012 (n = 298) across mental health (n = 333) and pediatrics outpatient clinics (n = 173) in the Netherlands and assessed adherence to seven guideline recommendations. Results: We did not find significant differences between 2008 and 2012 regarding the mean adherence to the seven recommendations (43% vs. 45%) or the percentage of off-label use (35% vs. 30%). Best adherence rates (over the years 2008 and 2012 combined) concerned the assessment of comorbidities (89%) and the involvement of teachers in the diagnostic process (75%). Least frequently adhered to were assessing ADHD severity (1%), the use of a (semi-)structured parent interview (16%), and providing psycho-education to parents (42%) or teachers (1%). Mental health settings showed better adherence than pediatrics settings (over the years 2008 and 2012 combined) concerning the use of (semi-)structured parent interviews (22% vs. 3.1%), having a separate diagnostic session directed at the child (81% vs. 63%), assessment of comorbidities (95% vs. 76%), and providing psycho-education to parents (51% vs. 24%). Conclusions: There was neither a decrease in adherence to guidelines nor an increase in off-label use between 2008 and 2012. However, there is ample room for improvement regarding guideline adherence. [ABSTRACT FROM AUTHOR]

Background: Methylphenidate may improve executive functioning in children with attention‐deficit/hyperactivity disorder (ADHD). However, it is unclear if there are still acute effects of methylphenidate on executive functioning after long‐term use. Methods: In a randomized double‐blind, placebo‐controlled discontinuation study, 94 children and adolescents (ages 8–18 years) who used methylphenidate beyond two years were either assigned to seven weeks of continued treatment with 36 or 54 mg of extended‐release methylphenidate or to gradual withdrawal over three weeks to placebo for four weeks. Performance on neuropsychological tasks, measuring working memory, response inhibition, attentional flexibility and psychomotor speed was compared between both groups using mixed models for repeated measures. Additionally, we investigated within the discontinuation group if a deterioration on the investigator‐rated Clinical Global Impressions Improvement scale after withdrawing to placebo was related to a worse performance on the neuropsychological tasks. This study was registered in the Netherlands Trial Register (www. Trialregister.nl) with identifier 5252. Results: After withdrawal of methylphenidate, the discontinuation group made more errors on working memory (β = −1.62, SD = 0.56, t = −2.88, p =.01, Cohen's f2 =.14), independent from reaction time compared to baseline, in contrast to the continuation group. We did not find differences in changes in response inhibition, attentional flexibility and psychomotor speed between the two groups. Also, there were no significant differences in task measures between the participants who deteriorated clinically and those who did not. Conclusions: Our study shows that methylphenidate has a beneficial effect on working memory after two years of use. Future studies should explore whether cognitive outcomes may aid clinical decision‐making on the continued use of methylphenidate, given dissociation between cognitive and behavioural effects of stimulant medication. [ABSTRACT FROM AUTHOR]

Antipsychotics are often prescribed to children and adolescents, mostly off-label. We aimed to assess adherence to recommendations of guidelines for antipsychotic prescription. We reviewed 436 medical records from 155 clinicians from 26 clinics within three Dutch child and adolescent psychiatry organizations (n = 398 outpatient, n = 38 inpatient care). We assessed target symptoms, diagnostic process, prior and concomitant treatment, and consideration of contra-indications. Multiple logistic regression assessed the role of age, sex, and psychiatric diagnosis on adherence to three main recommendations: to (1) prescribe antipsychotics only after other treatments proved insufficient, (2) always combine antipsychotics with psychosocial interventions, and (3) not prescribe multiple antipsychotics simultaneously. Most patients received off-label antipsychotics. Main target symptoms were inattention/hyperactivity (25%), aggression (24%), and other disruptive behaviors (41%). Most patients underwent diagnostic evaluation before the first prescription; however, screening of contra-indications was low (0.2–19%). About 84% had previously received psychosocial treatment and 48% other psychoactive medication, but 9% had not received any treatment. Notably, only 37% continuously received concomitant psychosocial treatment. Simultaneous use of multiple antipsychotics occurred in 3.2%. Younger children were at higher risk of non-adherence to guideline recommendations regarding prior and concomitant treatment, children with autism spectrum disorder or attention-deficit/hyperactivity disorder more likely not to receive concomitant psychosocial treatment. Sex did not significantly affect adherence. Our findings implicate insufficient adherence to important recommendations regarding antipsychotic use in children and adolescents. Especially younger children are at higher risk of receiving suboptimal care. There is an urgency to consistently offer psychosocial interventions during antipsychotic treatment. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate the relation between a variety of child, parent, family and environmental factors and pre-treatment motivation of parents of children and adolescents newly referred to a mental health care clinic in The Netherlands. Data were collected of 521 parents most involved in the upbringing of the child (443 mothers and 78 fathers; Dutch origin 97.1%) of 207 girls and 314 boys (age M = 10.2, range 1–18 years). Treatment motivation was measured by the Parent Motivation Inventory. Least absolute shrinkage and selection operator (LASSO) regression was used to investigate the prediction strength of 33 factors in 5 domains: (1) source of referral and prior use of healthcare services, (2) child characteristics, (3) characteristics of the primary parent, (4) parenting characteristics of the primary parent, and (5) family characteristics. Twenty-one factors were statistically relevant, explaining 21.3% of the deviance in pre-treatment motivation. Child characteristics, mainly type and severity of problems, contributed most to the model. Notably, internalising problems contributed more than externalising problems. Furthermore, we found relations between parental pre-treatment motivation and parents' perceived self-efficacy, parents' perceived parenting competence, financial problems and source of referral. Our findings provide insight into the multifacetedness of parental motivation prior to starting treatment and inform health professionals of specific contextual factors of interest in parents' readiness to change their behaviour and participate in treatment. [ABSTRACT FROM AUTHOR]

BACKGROUND: Genetics may partially explain observed heterogeneity in associations between traffic-related air pollution and incident asthma. OBJECTIVE: Our aim was to investigate the impact of gene variants associated with oxidative stress and inflammation on associations between air pollution and incident childhood asthma. METHODS: Traffic-related air pollution, asthma, wheeze, gene variant, and potential confounder data were pooled across six birth cohorts. Parents reported physician-diagnosed asthma and wheeze from birth to 7-8 years of age (confirmed by pediatric allergist in two cohorts). Individual estimates of annual average air pollution [nitrogen dioxide (NO2), particulate matter ≤ 2.5 μm (PM2.5), PM2.5 absorbance, ozone] were assigned to each child's birth address using land use regression, atmospheric modeling, and ambient monitoring data. Effect modification by variants in GSTP1 (rs1138272/Ala114Val and rs1695/IIe105Val) and TNF (rs1800629/G-308A) was investigated. RESULTS: Data on asthma, wheeze, potential confounders, at least one SNP of interest, and NO2 were available for 5,115 children. GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, respectively. In relation to air pollution exposure, children with one or more GSTP1 rs1138272 minor allele were at increased risk of current asthma [odds ratio (OR) = 2.59; 95% CI: 1.43, 4.68 per 10 μg/m3 NO2] and ever asthma (OR = 1.64; 95% CI: 1.06, 2.53) compared with homozygous major allele carriers (OR = 0.95; 95% CI: 0.68, 1.32 for current and OR = 1.20; 95% CI: 0.98, 1.48 for ever asthma; Bonferroni-corrected interaction p = 0.04 and 0.01, respectively). Similarly, for GSTP1 rs1695, associations between NO2 and current and ever asthma had ORs of 1.43 (95% CI: 1.03, 1.98) and 1.36 (95% CI: 1.08, 1.70), respectively, for minor allele carriers compared with ORs of 0.82 (95% CI: 0.52, 1.32) and 1.12 (95% CI: 0.84, 1.49) for homozygous major allele carriers (Bonferroni-corrected interaction p-values 0.48 and 0.09). There were no clear differences by TNF genotype. CONCLUSIONS: Children carrying GSTP1 rs1138272 or rs1695 minor alleles may constitute a susceptible population at increased risk of asthma associated with air pollution. [ABSTRACT FROM AUTHOR]

The article analyzes Dutch colonial policies in Indonesia in light of current debates about the (in)compatibility of Islam and modern democracy. The focus is on the work and life of Christiaan Snouck Hurgronje (1857-1936), who was simultaneously colonial advisor and the Netherlands' leading orientalist, and founding father of modern Islamic studies. The article investigates his way of dealing with the politicization of Islam in the Dutch East Indies and his attempt to combine counter-insurgency measures with modern institution-building in the early twentieth century. It argues that contemporary debates about the (in)compatibility of Islam and modernity are still premised on the sociological ideas and the image of Islam as a religion that have guided both Hurgronje's scholarly work and his colonial policies. [ABSTRACT FROM AUTHOR]

Two intensity-attenuation models for central Europe are presented in terms of mean relations and probability distributions of their variability. They are based on 14,714 intensity data points (IDP) of 31 earthquakes located in Germany, France, the Netherlands, and the Czech Republic. The attenuation relations are derived from crustal events with moment magnitudes Mw from 2.4 to 5.7, source depths h from 1 to 20 km, and epicentral distances R up to 400 km. Two different regression techniques are applied to derive the appropriate parameters a and b of the attenuation model I* - I = a log (√ (R² + h²)/h²) + b (√ R² + h²) - h). A combined weighted least-squares regression utilizing intensities and distances of the IDP in a direct way provides a = 2.80 and b = 0.0013. A chi-square regression method for mean intensity-class distances estimated by intensity-level binning gives a = 2.95 and b = 0.0025. The variabilities in the derived models can be described by normal distfibutions centered at the mean relation with a standard deviation of about 0.7 intensity units. This specification of attenuation variability is one of the advantages compared with former relations, making both attenuation models especially suitable to be applied in seismic hazard assessments. The two independent models can be regarded as an epistemic uncertainty in logic tree based hazard calculations. [ABSTRACT FROM AUTHOR]

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Despite their structural similarities the two countries have developed contrasting traditions about immigration: a broad consensus about pluralistic integration in the Netherlands, and bitter party conflicts spoiling the atmosphere in Germany. Regarding policy outcomes, however, we find that immigrants are less disadvantaged in Germany - a fact that has been much discussed in the Netherlands, bringing about a new policy of active integration. We conclude that integration processes can be very specific and that multicultural programmes can carry powerful messages of exclusion. [ABSTRACT FROM AUTHOR]

Standard schemes for classifying educational attainment have been developed in response to the noncomparability of the credentials awarded by different societies' educational systems. The ISCED and CASMIN schemes are the most widely used. To use these standard classification schemes, each society's indigenous credentials must be reclassified into the standard categories. This article shows that the CASMIN scheme reproduces the education-occupation association produced by the indigenous credentials more closely for Great Britain and The Netherlands, while ISCED does so for the United States. Weaknesses in the CASMIN scheme for the United States are identified, and a revised CASMIN scheme is proposed. The revised CASMIN scheme is a great improvement over the original for the United States and a slight improvement for Great Britain and The Netherlands. [ABSTRACT FROM AUTHOR]

Assesses the relationship of European fascism embodied in the Dutch Nationaal Socialistische Beweging (NSB) party and Nazi Germany from 1933 to 1940. Perceptions of the NSB on Italian and German fascism; Leadership of Adriaan Anton Mussert; Parallelism of NSB and the German Nazi party; Institutions and programs copied by the NSB from the German Nazi party.

Case Description—A 1-year-old sexually intact female Netherland dwarf rabbit was examined because of a 3-week history of signs of lethargy, decreased appetite, left unilateral exophthalmia, a previous draining sinus from a left maxillary facial abscess, and bilateral nasal discharge. Clinical Findings—The rabbit weighed 1.0 kg (2.2 lb) and had a body condition score of 1.5/5. Physical examination revealed generalized muscle atrophy, bilateral mucopurulent nasal discharge, and severe left-sided exophthalmia. Diagnostic investigation revealed anemia, neutrophilia, severe dental disease, a superficial corneal ulcer of the left eye, and a retrobulbar abscess. Treatment and Outcome—Stomatoscopy-aided dental trimming, tooth removal, and abscess debridement were performed. Antimicrobials were flushed into the tooth abscess cavity, and antimicrobial treatment was initiated on the basis of cytologic findings and results of bacterial culture and susceptibility testing. Two months after the initial surgery, minimal exophthalmia was evident and no further physical, radiographic, or ultrasonographic changes were evident. Clinical Relevance—Stomatoscopy is a valuable technique that can facilitate diagnosis, treatment, and serial reevaluation of rabbits with dental disease. [ABSTRACT FROM AUTHOR]