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The China–Nepal Transportation Corridor is vital to the country's efforts to build a land trade route in South Asia and promote the Ring-Himalayan Economic Cooperation Belt. Due to the complex geological structure and topographical environment of the Qinghai–Tibet Plateau, coupled with the impact of climate change, the frequent occurrence of geological disasters has increased the operational difficulty of the China–Nepal Highway and the construction difficulty of the China–Nepal Railway. However, to date, there has been no systematic study of the spatial distribution of landslides along the entire route within the area, the factors influencing landslides at different scales, or the causes of landslides under different topographic backgrounds. There is an even greater lack of research on areas threatened by potential landslides. This study comprehensively applies remote sensing, mathematical statistics, and machine learning methods to map landslides along the China–Nepal transportation corridor, explore the influencing factors and causes of different types of landslides, and investigate the distribution characteristics of potential landslides. A total of 609 historic landslides have been interpreted in the study area and were found to be distributed along faults and locally concentrated. The strata from which landslides develop are relatively weak and are mainly distributed within 2 km of a fault with a slope between 20° and 30°. The direction of slope for the majority of landslides is south to south-west, and their elevation is between 4000 and 5000 m. In addition, we discovered a power law relationship between landslide area and volume (VL = 2.722 × AL1.134) and determined that there were 47 super-large landslides, 213 large landslides, and 349 small and medium-sized landslides in the area, respectively. Slope is the most significant influencing factor for the development of landslides in the area. Apart from slope, faults and strata significantly influence the development of large and medium-small landslides, respectively. We have identified 223 potential landslides in the region, 15 of which directly threaten major transport routes, mainly in the Renbu Gorge section of the China–Nepal Highway and the proposed China–Nepal Railway section from Peikucuo to Gyirong County. In addition, we also discussed the causes of landslides within three geomorphic units in the region. First, the combined effects of faulting, elevation, and relatively weak strata contribute to the development of super-large and large landslides in the Gyirong basin and gorge. Second, the relatively weak strata and the cumulative damaging effects of earthquakes promote the development of small and medium-sized landslides in the Xainza-Dinggye rift basin. Third, under the combined effect of the hanging wall effect of thrust faults and the relatively weak material composition, landslides of various types have developed in the Nagarzê mountain. It is worth noting that potential landslides have developed in all three geomorphic units mentioned above. This study provides data and theory to assist in the accurate mitigation and control of landslide hazards in the corridor. [ABSTRACT FROM AUTHOR]