1. Antibacterial and antiviral naphthazarins from Maharanga bicolor.
- Author
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Rajbhandari M, Schoepke TH, Mentel R, and Lindequist U
- Subjects
- Animals, Antineoplastic Agents, Phytogenic pharmacology, Bacillus subtilis drug effects, Cell Line, Tumor, Chlorocebus aethiops, Dogs, Enterococcus drug effects, Gram-Positive Bacteria drug effects, Herpesvirus 1, Human drug effects, Influenza A virus drug effects, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Naphthoquinones isolation & purification, Nepal, Plant Extracts chemistry, Solvents, Spectrometry, Mass, Electrospray Ionization, Spectrophotometry, Ultraviolet, Staphylococcus drug effects, Structure-Activity Relationship, Vero Cells, Anti-Bacterial Agents, Antiviral Agents, Boraginaceae chemistry, Naphthoquinones pharmacology
- Abstract
Maharanga bicolor, Boraginaceae, is used in the Nepalese ethnomedicine for the treatment of several diseases. In the course of screening investigations the dichloromethane extract of the roots of Maharanga bicolor was found to inhibit the growth of gram positive bacteria. Bio-assay directed fractionation led to the isolation of five active naphthazarins, deoxyalkannin (1), alkannin (2), acetylalkannin (3), alkannin beta-hydroxyisovalerate (4) and alkannin beta-acetoxyisovalerate (5). Compounds 2-5 showed antibacterial activity against multi resistant human pathogenic Staphylococcus and Enterococcus species and 1, 4 and 5 showed antiviral activity against herpes simplex virus type-1.
- Published
- 2007