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Simple Summary: The Far-Eastern Himalayan Landscape, a global biodiversity hotspot spread across parts of India, Myanmar, and China, holds great potential for the long-term conservation of tiger populations. National-level efforts aimed at tiger conservation, such as the creation of protected areas, have been critical for the survival of key tiger populations. However, for tigers to continue to survive into the future, it is important that these key populations remain connected with each other, particularly in this transboundary landscape. This requires greater regional and cross-border co-operation in conservation research, monitoring, and planning to protect habitats and corridors. Here, we review and synthesize the available literature on two decades of conservation efforts aimed at the study and conservation of tigers, their co-predators, and prey in the landscape to understand research trends, identify knowledge gaps, and suggest priority areas for future research and conservation interventions. This review could be useful for formulating conservation plans and actions that could help in the recovery of tiger populations; for identifying, restoring, and securing connectivity between key tiger habitats; and for addressing other key threats, such as habitat loss, poaching, and trade in wildlife parts. Addressing the effects of human-caused habitat destruction on free-ranging threatened large carnivores requires actions that go 'beyond borders' in conserving and protecting their habitat and prey base. In this review, we compiled information from available literature on 20 years of conservation efforts aimed at tigers, co-predators, and their prey in the Far-Eastern Himalayan Landscape that is situated at the confluence of three global biodiversity hotspots covering parts of India, Myanmar, and China. The vast area of the proven biodiversity-rich forested landscape is highly suitable for long-term survival of carnivores, such as tigers. Habitat loss, ritual hunting, commercial exploitation, and poaching are the prevailing threats that have resulted in low tiger, co-predator, and prey population densities. Studies suggest that tiger presence is confined to a few areas, while other tiger populations have been extirpated across most parts of the landscape. Past research also suggests that the landscape holds low abundance of diverse prey species richness (n = 22), and urgent conservation measures are required to improve their habitat and numbers. This calls for greater regional and transboundary co-operation on research and knowledge sharing, conservation awareness programs for locals, and cross-border co-operation on wildlife monitoring. Strict policies are also required to enable PA managers to develop strategic plans to conserve large predators and protect their habitats and corridors. [ABSTRACT FROM AUTHOR]