Search

A recent report from the Russian Academy of Sciences discusses the use of bismuth nanoparticles (Bi NPs) to enhance proton therapy for the treatment of tumors. The researchers prepared spherical Bi NPs and observed efficient cell death after proton irradiation, resulting in a significant inhibition of tumor cell activity. In vivo experiments on mice with sarcoma tumors showed a decrease in primary tumor growth and metastatic potential. The researchers concluded that Bi NPs-enhanced proton therapy has the potential to greatly improve cancer treatment. This research has been peer-reviewed and published in Materials Today Nano. [Extracted from the article]

The article focuses on a study conducted at Pirogov Russian National Research Medical University investigating the role of microRNA-155 (miRNA-155) in cancer and inflammation, which found that miRNA-155 is involved in regulating gene expression and cytokine production, potentially altering cancer progression.

Researchers at Moscow MV Lomonosov State University have proposed a new approach to the development of peroral iron drug delivery systems for the treatment of iron deficiency anemia. The systems are based on polymethylsilsesquioxane hydrogels, which are biocompatible and biodegradable supports. The hydrogels have shown a high sorption capacity for iron chloride and iron D-gluconate solutions. The researchers believe that these delivery systems have potential for the development of drug formulations. This research has been peer-reviewed and funded by the Program of Development of the Moscow State University and the Russian Science Foundation. [Extracted from the article]

A recent study conducted at the Nasonova Research Institute of Rheumatology in Moscow, Russia, explored the effectiveness of the IL-6 inhibitor olokizumab (OKZ) in reducing symptoms of depression in patients with rheumatoid arthritis (RA). The study included 49 RA patients, predominantly women, with high RA activity and depression. The patients were divided into three groups and received different treatments, including OKZ and psychopharmacotherapy (PPT). After 12 and 24 weeks of therapy, all groups showed a significant decrease in the severity of depression and anxiety. However, the groups receiving PPT in addition to OKZ showed a greater reduction in symptoms. The study concluded that a combination of OKZ and PPT is optimal for the regression of depression and anxiety in RA patients. [Extracted from the article]

A new study from Sechenov First Moscow State Medical University in Russia explores the possibilities of antiarrhythmic therapy for atrial fibrillation (AF), the most common heart rhythm disorder. The study highlights three main treatment directions for AF: anticoagulant therapy, control of arrhythmia symptoms, and treatment of concomitant diseases and risk factors. The research discusses various strategies for rhythm control, including cardioversion, long-term antiarrhythmic therapy, and radiofrequency catheter ablation. The study also emphasizes the ongoing search for new drugs to prevent and treat AF at the molecular level. [Extracted from the article]

A report from the National Research University Higher School of Economics in Moscow, Russia, discusses the use of quantum dots (QDs) in various applications. QDs are semiconductor nanocrystals with unique properties, such as optical and electrical properties. They have potential applications in bioimaging, drug delivery, therapy, and biosensors. The research also highlights the use of QDs in the accurate detection and inhibition of SARS-CoV-2. The study has been peer-reviewed and provides valuable insights into the innovative methods of therapy using quantum dots. [Extracted from the article]

A new study conducted by researchers at the Nasonova Research Institute of Rheumatology in Moscow, Russia, evaluated the effectiveness of upadacitinib (UPA) therapy in patients with rheumatoid arthritis (RA) in real clinical practice. The study included 63 RA patients with high disease activity and assessed various factors such as disease activity, functional ability, quality of life, and depression and anxiety levels. The results showed that after 3 and 6 months of UPA therapy, most patients achieved remission or low disease activity, with a significant improvement in functional state and quality of life. The study also found that UPA therapy reduced the need for nonsteroidal anti-inflammatory drugs (NSAIDs) and decreased the dose of glucocorticoids (GC) in a third of patients. [Extracted from the article]

A recent report from researchers at Pirogov Russian National Research Medical University in Moscow, Russia, discusses the findings of a study on the antitumor activity of antiestrogen-cytostatics and their binding affinity with estrogen receptors. The study focused on compounds Ro-714, Ro-716, and Ro-728, which showed significant antitumor activity in animal models. The researchers used a molecular docking approach to predict the binding affinity of these compounds with estrogen receptor subtypes alpha and beta (ER alpha and ER beta). The study concluded that the antitumor effects of these compounds may depend on the ratio of ER alpha and ER beta subtypes in a malignant formation. This research has been peer-reviewed and published in the Pharmaceutical Chemistry Journal. [Extracted from the article]

A study conducted by the Mental Health Research Center in Moscow, Russia, explores the relationship between energy metabolism and schizophrenia. The researchers suggest that impairments in brain energy metabolism may be a contributing factor to the development of schizophrenia, but more research is needed to determine if these impairments are primary causes or secondary effects of other changes in the brain. The study also discusses potential therapeutic approaches targeting energy metabolism in schizophrenia, although the efficacy of these approaches has not been proven. The researchers recommend further analysis to identify patient subgroups that may benefit from energy metabolism-targeted therapy. [Extracted from the article]

A study conducted by the Russian Academy of Sciences investigated the effects of a multivitamin complex on the antioxidant system in the blood plasma of individuals exposed to low-intensity radiation, including Chernobyl disaster liquidators and children living in contaminated areas. The study found that oral therapy with the multivitamin complex led to the normalization of the antioxidant system in the blood plasma of the exposed individuals in the early stages. However, the effectiveness of the therapy decreased after ten months due to the consumption of antioxidants in the blood plasma. The researchers concluded that further study is needed to understand the therapeutic effects of vitamin preparations and reduce potential health risks associated with low-dose ionizing radiation exposure. [Extracted from the article]

A study conducted by investigators from I.M. Sechenov First Moscow State Medical University in Russia examined the prescribing trends and adherence to medication in elderly patients. The study found that finding the right medication and dosage for elderly patients is challenging. The researchers discovered that a high percentage of elderly patients were prescribed multiple medications simultaneously, leading to low adherence to treatment. Factors contributing to low adherence included the complexity of the drug regimen, high cost of drugs, lack of knowledge about the disease, and a lack of understanding of the necessity for drug intake. The study concluded that optimizing pharmacotherapy for elderly patients requires considering their unique physiological changes, the characteristics of prescribed drugs, and the prevalence of multiple diseases and low adherence to treatment. [Extracted from the article]

A recent study conducted in Moscow, Russia, has provided new insights into breast cancer and its sensitivity to retinoic acid (RA), a potential therapeutic agent. The study focused on the role of Cellular Retinoic Acid Binding Proteins (CRABP1 and CRABP2) in regulating cellular sensitivity to RA and their effects on cell proliferation. The researchers found that CRABP1 and CRABP2 have opposing effects on proliferation and sensitivity to RA in breast cancer cells, with their effects depending on the baseline level of RA-sensitivity. This research contributes to a better understanding of the mechanisms of resistance to RA in breast cancer cells. [Extracted from the article]

A recent study conducted at N.E. Bauman Moscow State Technical University in Russia has explored the potential of personalized medicine in the field of cryotherapy. Cryotherapy is a medical treatment that stimulates the body's surface using a physical factor. The researchers aimed to improve cryotherapy by increasing the number of parameters and achieving a more uniform skin temperature distribution. The study concluded that their approach could enhance cryotherapy protocols and contribute to equipment development. This research has been peer-reviewed and published in the International Journal of Refrigeration. [Extracted from the article]

A recent study conducted by researchers from the Russian Academy of Sciences has focused on the leukocyte common antigen CD45, which is a receptor tyrosine phosphatase found on the surface of blood cells. The study aimed to understand the molecular mechanisms behind CD45's role in transmitting signals from T-cell receptors and chimeric antigen receptors, as well as its impact on lymphocytes and T cells modified by chimeric antigen receptors. The researchers emphasized the importance of comprehending CD45's structural features and its function in regulating immune system cell activation for the study of oncological diseases. The study was supported by the Russian Science Foundation and has been peer-reviewed. [Extracted from the article]

A clinical trial, NCT06114498, is underway in Moscow to create a Hospital Register of patients with heart failure with preserved ejection fraction (HFpEF). The study aims to assess various factors such as gender characteristics, clinical indicators, comorbid status, drug therapy, and outcomes in patients with acute decompensated HFpEF. Additionally, the study will analyze body composition, congestion characteristics, and biomarkers associated with cellular stress. The results will help evaluate the course and outcomes of the disease in Moscow patients and identify phenotypes that affect hospitalization duration and adverse outcomes. The study is currently recruiting participants and is expected to be completed by December 2025. [Extracted from the article]

Researchers at the National Medical Research Center in Moscow, Russia, have conducted a study on the effectiveness of a polymer hydrogel containing an antibiotic for the treatment of chronic osteomyelitis. The study was performed on the lower leg of 25 rabbits, comparing the hydrogel with the commonly used polymethyl methacrylate (PMMA) depot system. The results showed that the hydrogel effectively stopped chronic osteomyelitis without the need for additional systemic antibiotic therapy and did not cause bone resorption. This research suggests that the hydrogel may be a promising alternative treatment for chronic osteomyelitis. [Extracted from the article]

Keywords: Moscow; Russia; ADHD; Attention Deficit Hyperactivity Disorders; Developmental Diseases and Conditions; Drugs and Therapies; Health and Medicine; Mental Health; Pharmacotherapy; Therapy EN Moscow Russia ADHD Attention Deficit Hyperactivity Disorders Developmental Diseases and Conditions Drugs and Therapies Health and Medicine Mental Health Pharmacotherapy Therapy 898 898 1 09/04/23 20230908 NES 230908 2023 SEP 8 (NewsRx) -- By a News Reporter-Staff News Editor at Mental Health Weekly Digest -- Current study results on Developmental Diseases and Conditions - Attention Deficit Hyperactivity Disorders have been published. The most common NDD forms that doctors of various specialties constantly encounter include speech development disorders and attention deficit hyperactivity disorder (ADHD). Keywords for this news article include: Moscow, Russia, ADHD, Attention Deficit Hyperactivity Disorders, Developmental Diseases and Conditions, Drugs and Therapies, Health and Medicine, Mental Health, Pharmacotherapy, Therapy, Pirogov Russian National Research Medical University. [Extracted from the article]

Keywords: Moscow; Russia; Obesity Fitness and Wellness; Health and Medicine; Therapy EN Moscow Russia Obesity Fitness and Wellness Health and Medicine Therapy 846 846 1 09/04/23 20230905 NES 230905 2023 SEP 5 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators discuss new findings in Obesity, Fitness and Wellness. Moscow, Russia, Obesity Fitness and Wellness, Health and Medicine, Therapy According to the news editors, the research concluded: "A significant part of the review is devoted to consideration of a new strategy for treatment of oncological diseases - use of the directed enzyme prodrug therapy approach aiming to obtain antitumor thiosulfinates in situ.". [Extracted from the article]

Namely, we developed an oncotheranostic platformthat is based on PLGA nanoparticles and possesses red/green lightdual-activated diagnostic/therapeutic properties for HER2-targetedphotodynamic therapy of aggressive breast cancer. Keywords: Moscow; Russia; Biotechnology; Breast Cancer; Cancer; Diagnostics and Screening; Drugs and Therapies; Emerging Technologies; Health and Medicine; Nanoagents; Nanoparticles; Nanotechnology; Oncology; Pharmaceuticals; Photodynamic Therapy; Photodynamics; Phototherapy; Therapy; Women's Health EN Moscow Russia Biotechnology Breast Cancer Cancer Diagnostics and Screening Drugs and Therapies Emerging Technologies Health and Medicine Nanoagents Nanoparticles Nanotechnology Oncology Pharmaceuticals Photodynamic Therapy Photodynamics Phototherapy Therapy Women's Health 886 886 1 07/24/23 20230728 NES 230728 2023 JUL 25 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Data detailed on Oncology - Breast Cancer have been presented. [Extracted from the article]

Keywords: Moscow; Russia; Adrenal Cortex Hormones; Glucocorticoids; Pediatrics; Therapy EN Moscow Russia Adrenal Cortex Hormones Glucocorticoids Pediatrics Therapy 85 85 1 06/19/23 20230623 NES 230623 2023 JUN 24 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- Investigators publish new report on Hormones - Adrenal Cortex Hormones. We evaluated the effectiveness of an early-intervention algorithm for atopic dermatitis treatment, utilizing pimecrolimus for long-term maintenance therapy, in reducing transcutaneous sensitization in infants.". [Extracted from the article]

Moscow, Russia, Amino Acids, Drug Delivery Systems, Drugs and Therapies, Emerging Technologies, Enzymes and Coenzymes, Essential Amino Acids, Health and Medicine, Lyases, Methionine, Nanocapsules, Nanoreactors, Nanotechnology, Neutral Amino Acids, Sulfur Amino Acids, Therapy Keywords: Moscow; Russia; Amino Acids; Drug Delivery Systems; Drugs and Therapies; Emerging Technologies; Enzymes and Coenzymes; Essential Amino Acids; Health and Medicine; Lyases; Methionine; Nanocapsules; Nanoreactors; Nanotechnology; Neutral Amino Acids; Sulfur Amino Acids; Therapy EN Moscow Russia Amino Acids Drug Delivery Systems Drugs and Therapies Emerging Technologies Enzymes and Coenzymes Essential Amino Acids Health and Medicine Lyases Methionine Nanocapsules Nanoreactors Nanotechnology Neutral Amino Acids Sulfur Amino Acids Therapy 771 771 1 06/05/23 20230606 NES 230606 2023 JUN 6 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- Fresh data on Nanotechnology - Nanoreactors are presented in a new report. [Extracted from the article]

Moscow, Russia, Bone Research, Cryotherapy, Health and Medicine, Surgical Procedures, Therapeutics, Therapy Keywords for this news article include: Moscow, Russia, Bone Research, Cryotherapy, Health and Medicine, Surgical Procedures, Therapeutics, Therapy, N.E. Bauman Moscow State Technical University. Keywords: Moscow; Russia; Bone Research; Cryotherapy; Health and Medicine; Surgical Procedures; Therapeutics; Therapy EN Moscow Russia Bone Research Cryotherapy Health and Medicine Surgical Procedures Therapeutics Therapy 192 192 1 05/08/23 20230514 NES 230514 2023 MAY 14 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Investigators discuss new findings in Surgical Procedures - Cryotherapy. [Extracted from the article]

According to the news editors, the research concluded: "The validated method could be recommended for RPH-104 quantification in patient blood serum to personalize the efficacy of pharmacotherapy and to monitor treatment." Keywords: Moscow; Russia; Obesity Fitness and Wellness; Drugs and Therapies; Health and Medicine; Pharmacotherapy; Therapy EN Moscow Russia Obesity Fitness and Wellness Drugs and Therapies Health and Medicine Pharmacotherapy Therapy 1593 1593 1 04/24/23 20230428 NES 230428 2023 APR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Obesity, Fitness and Wellness. Moscow, Russia, Obesity Fitness and Wellness, Drugs and Therapies, Health and Medicine, Pharmacotherapy, Therapy. [Extracted from the article]

Keywords: Moscow; Russia; Cardiotonic; Deuterium; Drugs and Therapies; Health and Medicine; Isotopes; Ouabain Therapy; Pharmaceuticals; Pharmacology; Therapy EN Moscow Russia Cardiotonic Deuterium Drugs and Therapies Health and Medicine Isotopes Ouabain Therapy Pharmaceuticals Pharmacology Therapy 326 326 1 04/10/23 20230414 NES 230414 2023 APR 14 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Drugs and Therapies - Ouabain Therapy. Moscow, Russia, Cardiotonic, Deuterium, Drugs and Therapies, Health and Medicine, Isotopes, Ouabain Therapy, Pharmaceuticals, Pharmacology, Therapy. [Extracted from the article]

Moscow, Russia, Acute-Phase Proteins, Albumins, Blood Proteins, Drugs and Therapies, Health and Medicine, Pharmacotherapy, Proteins, Serum Albumin, Therapy Keywords: Moscow; Russia; Acute-Phase Proteins; Albumins; Blood Proteins; Drugs and Therapies; Health and Medicine; Pharmacotherapy; Proteins; Serum Albumin; Therapy EN Moscow Russia Acute-Phase Proteins Albumins Blood Proteins Drugs and Therapies Health and Medicine Pharmacotherapy Proteins Serum Albumin Therapy 2023 MAR 3 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- A new study on Proteins - Blood Proteins is now available. [Extracted from the article]