1. Diterpenoids from Tetraclinis articulata that inhibit various human leukocyte functions.
- Author
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Barrero AF, Quílez del Moral JF, Lucas R, Payá M, Akssira M, Akaad S, and Mellouki F
- Subjects
- Diterpenes chemistry, Diterpenes pharmacology, Humans, Luminescent Measurements, Molecular Structure, Morocco, Neutrophils enzymology, Nuclear Magnetic Resonance, Biomolecular, Pancreatic Elastase drug effects, Pancreatic Elastase metabolism, Peroxidase drug effects, Peroxidase metabolism, Plant Leaves chemistry, Stereoisomerism, Wood, Cupressaceae chemistry, Diterpenes isolation & purification, Leukocytes drug effects, Leukocytes enzymology, Plants, Medicinal chemistry
- Abstract
Ten new compounds, eight of them pimarane derivatives (1-8), together with a menthane dimer (9) and a totarane diterpenoid (10), were isolated from the leaves and wood of Tetraclinis articulata. The structures of 1-10 were established by using spectroscopic techniques, including 2D NMR spectra. Pimaranes 1-5 were found to possess an unusual cis interannular union of the B and C rings, which, from a biogenetic perspective, could be derived from the hydration of a carbocation at C-8. Compounds 4-6 and a mixture of 7 and 11 modulated different human leukocyte functions at a concentration of 10 microM, mainly the degranulation process measured as myeloperoxidase release and, to a lesser extent, the superoxide production measured by chemiluminescence.
- Published
- 2003
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