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Background and Aim: Approximately half of patients with Crohn's disease (CD) who have surgery will experience clinical recurrence within 10 years of their surgery. This study aimed to assess the postoperative outcomes according to disease location and validated the simple endoscopic score for CD (SES‐CD) to predict disease‐related outcomes. Methods: We retrospectively assessed medical records of CD patients who underwent ileocolonoscopy within 12 months after surgery at the University of Chicago between 2005 and 2016. We defined patients with postoperative colonic inflammation at the first postoperative ileocolonoscopy or had Montreal classification L2 as colon‐dominant disease and patients without colonic involvement or who had L1 as small intestine (SI)‐dominant disease. The outcomes included clinical and surgical recurrence. Results: Among 207 CD patients, 51 (24.6%) and 156 (75.4%) patients had colon‐dominant and SI‐dominant disease, respectively. Patients with colon‐dominant disease had a greater risk of postoperative clinical recurrence compared with those with SI‐dominant disease (P = 0.018). Colon‐dominant disease was a risk of earlier surgical recurrence compared with SI‐dominant disease, although there were no significant differences in the recurrence‐free survivals. SES‐CD > 2 at the first postoperative ileocolonoscopy was a significant risk of clinical recurrence on log‐rank test (P < 0.001) and Cox proportional hazards model (hazard ratio = 2.25; 95% confidence interval = 1.14–4.47; P = 0.020). An SES‐CD of 1 was an appropriate cut‐off to predict the clinical recurrence of SI‐dominant disease, but a higher SES‐CD cut‐off value of 5 was required for colon‐dominant disease. Conclusions: We demonstrated that SES‐CD predicts postoperative clinical recurrence of CD, regardless of disease location. [ABSTRACT FROM AUTHOR]