1. AMPA workshop on challenges faced by investigators conducting Alzheimer's disease clinical trials.
- Author
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Vellas B, Pesce A, Robert PH, Aisen PS, Ancoli-Israel S, Andrieu S, Cedarbaum J, Dubois B, Siemers E, Spire JP, Weiner MW, and May TS
- Subjects
- Cholinesterase Inhibitors therapeutic use, Databases, Factual statistics & numerical data, Humans, International Cooperation, Monaco, Patient Rights, Patient Selection, Alzheimer Disease drug therapy, Clinical Trials as Topic methods, Excitatory Amino Acid Antagonists therapeutic use, Memantine therapeutic use, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid metabolism
- Abstract
The recruitment and retention of patients are among the greatest challenges currently being faced by researchers who conduct Alzheimer's disease (AD) clinical trials. To discuss these challenges and other major issues associated with clinical research in AD, an international workshop was organized by the Association Monégasque pour la recherche sur la Maladie d'Alzheimer at Monte Carlo, Monaco, in February 2010, with the participation of leading research experts in the field of Alzheimer's. Key topics discussed were as follows: (1) the selection, recruitment, and retention of clinical trial subjects; (2) international co-operation among researchers; and (3) patient rights and informed consent for participants in clinical trials. This article highlights some of the challenges faced by investigators when conducting clinical trials in AD, and it also offers some recommendations aimed at overcoming these challenges., (Copyright © 2011 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.)
- Published
- 2011
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