1. PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations.
- Author
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Hatano Y, Sato K, Elibol B, Yoshino H, Yamamura Y, Bonifati V, Shinotoh H, Asahina M, Kobayashi S, Ng AR, Rosales RL, Hassin-Baer S, Shinar Y, Lu CS, Chang HC, Wu-Chou YH, Ataç FB, Kobayashi T, Toda T, Mizuno Y, and Hattori N
- Subjects
- Age of Onset, Asia epidemiology, Chromosome Disorders ethnology, Chromosome Disorders metabolism, Chromosome Mapping, DNA Mutational Analysis, Female, Gene Frequency genetics, Genetic Linkage genetics, Genetic Markers genetics, Genetic Testing, Haplotypes genetics, Humans, Male, Microsatellite Repeats genetics, Middle East epidemiology, Parkinson Disease ethnology, Parkinson Disease metabolism, Pedigree, Chromosome Disorders genetics, Genes, Recessive genetics, Genetic Predisposition to Disease genetics, Mutation genetics, Parkinson Disease genetics, Protein Kinases genetics
- Abstract
The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod) score of 9.88 at D1S2732. The results indicate worldwide distribution of PARK6-linked parkinsonism.
- Published
- 2004
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