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• Cyber-physical system collects matched bridge input (truck loads) and output data. • Site-specific load rating parameters derived from bridge responses and truck weight data. • Data-driven load rating method leads to more accurate rating factors. • Two operational bridges rated using proposed method for evaluation. Load rating is a widely used approach for evaluating the load-carrying capacity of bridges in an effort to ensure safe bridge operation under expected traffic loads. Load rating often relies on simplified analytical models including empirically derived model parameters that do not reflect bridge-specific information resulting in conservative ratings. To reduce this conservatism, this study proposes a novel data-driven framework that utilizes long-term bridge response data to extract bridge-specific model parameters that can be used within in the Load and Resistance Factor Rating (LRFR) process. The data-driven LRFR (DD-LRFR) framework is empowered by a cyber-physical system (CPS) architecture that uses Internet connectivity to integrate measured bridge responses with truck weights measured by a weigh-in-motion (WIM) station. The CPS architecture uses computer vision of camera images to confirm trucks observed at a WIM station are identical to those observed at a bridge. Bridge response and axle weight data are then used to extract probabilistic models of dynamic load allowances and unit influence lines. The DD-LRFR method is validated using a 20-mile (32.2-km) segment of the I-275 northbound highway in Michigan that is monitored continuously by the CPS architecture. Six girders associated with two bridges along I-275 are rated using the proposed DD-LRFR methodology with rating factors compared to those obtained using conventional and refined load rating methods. The DD-LRFR method yields inventory- and operational-level rating factors that are less conservative than those from the approximate LRFR method and comparable to those using finite element modeling of the bridge. [ABSTRACT FROM AUTHOR]