1. Evolution of Zika prevalence in a dengue hyperendemic municipality in Southern Mexico after the outbreak of 2015 to 2017.
- Author
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Gaspar-Castillo, Carlos, Cortes-Escamilla, Anais, Aparicio-Antonio, Rodrigo, Carnalla, Martha, López, Susana, Sánchez-Tacuba, Liliana, Oceguera-Cabrera, Alfonso, Burrone, Oscar, González-Bonilla, César, Ortiz-Navarrete, Vianney, Martínez-Barnetche, Jesús, Henry Rodríguez, Mario, and Alpuche-Aranda, Celia M.
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DENGUE , *FLAVIVIRUSES , *TITERS , *SEROPREVALENCE - Abstract
Objective. Estimate the Zika prevalence in a dengueendemic municipality in Mexico, after the outbreak of 2015 to 2017. Materials and methods. Three serosurveys were conducted in Tapachula, Chiapas, in September 2018, March 2019 and November 2019. A commercial ZIKV and DENV anti-NS1 IgG ELISA were used to estimate each prevalence, their performance and adjustment of the cut-off value were compared with an in-house DENVs and ZIKV anti-EDIII IgG ELISA and the microneutralization test. Results. The anti-NS1 ZIKV titers decreased over time, causing that Zika prevalence decreased from 78.02 to 45.22%, while anti-NS1 DENV titers increased, and the prevalence remained above 95% over a two-year period. Conclusion. Optimal Zikaprevalence estimates can be obtained in a two-years period after outbreaks in dengue-endemic areas. The extension of the Zika outbreak is significantly higher than previously reported in Tapachula, highlighting the underreport of cases based on the routine flavivirus surveillance system in Mexico. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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