1. Geotrichum spp: An overlooked and fatal etiologic agent in immunocompromised patients. A case series from a referral center in Mexico.
- Author
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Rajme-López S, González-Lara MF, Martínez-Gamboa RA, Rangel-Cordero A, and Ponce-de-León A
- Subjects
- Animals, Antifungal Agents therapeutic use, Geotrichum, Humans, Immunocompromised Host, Male, Mexico epidemiology, Referral and Consultation, Hematologic Neoplasms complications, Hematologic Neoplasms veterinary, Invasive Fungal Infections drug therapy, Invasive Fungal Infections veterinary, Respiratory Tract Infections drug therapy, Respiratory Tract Infections veterinary
- Abstract
Geotrichum spp. is an emergent pathogen. We aimed to describe Geotrichum spp. invasive fungal infections (IFI) in patients from Mexico. We reviewed cases with Geotrichum spp. isolated in clinical samples, from 2001 to 2019. Descriptive analysis was used for clinical data. Twenty patients with proven/probable Geotrichum spp. IFI were analyzed. The median age was 43; 55% were males. Hematologic malignancy was found in 60% (12/20); 75% (15/20) received systemic immunosuppressors. The most common presentation was lower respiratory tract infection. In-hospital mortality was 45% (9/20). Geotrichum spp. should be acknowledged as a pathogen causing atypical pneumonia in immunocompromised Latin American patients., Lay Summary: Geotrichum spp. causes invasive infection in immunocompromised hosts. We describe a case series of 20 patients from Mexico City. Hematologic malignancy was the most common comorbidity. Clinical presentation was mainly lower respiratory tract infection. Mortality was high despite antifungal therapy., (© The Author(s) 2022. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.)
- Published
- 2022
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