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A report from the Burnet Institute in Melbourne, Australia discusses the findings of a study on the RTS,S malaria vaccine. The vaccine is recommended for children aged 5-6 months in regions with moderate-to-high Plasmodium falciparum transmission, but its efficacy is limited and wanes over time. The study aimed to identify antibody response types associated with protection against malaria in children vaccinated with RTS,S. The researchers found that functional antibody responses mediated by IgG and IgA were associated with protection against malaria in young children, and there may be differences in the correlates of immunity between males and females. These findings could potentially lead to the development of more effective malaria vaccines. [Extracted from the article]