1. Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals.
- Author
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Vernot B, Tucci S, Kelso J, Schraiber JG, Wolf AB, Gittelman RM, Dannemann M, Grote S, McCoy RC, Norton H, Scheinfeldt LB, Merriwether DA, Koki G, Friedlaender JS, Wakefield J, Pääbo S, and Akey JM
- Subjects
- Animals, Genetic Variation, Humans, Melanesia, Sequence Analysis, DNA, DNA genetics, Genome, Human genetics, Native Hawaiian or Other Pacific Islander genetics, Neanderthals genetics
- Abstract
Although Neandertal sequences that persist in the genomes of modern humans have been identified in Eurasians, comparable studies in people whose ancestors hybridized with both Neandertals and Denisovans are lacking. We developed an approach to identify DNA inherited from multiple archaic hominin ancestors and applied it to whole-genome sequences from 1523 geographically diverse individuals, including 35 previously unknown Island Melanesian genomes. In aggregate, we recovered 1.34 gigabases and 303 megabases of the Neandertal and Denisovan genome, respectively. We use these maps of archaic sequences to show that Neandertal admixture occurred multiple times in different non-African populations, characterize genomic regions that are significantly depleted of archaic sequences, and identify signatures of adaptive introgression., (Copyright © 2016, American Association for the Advancement of Science.)
- Published
- 2016
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