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1. Sulfated steroids: ptilosteroids A-C and ptilosaponosides A and B from the Solomon Islands marine sponge Ptilocaulis spiculifer.

Author

Gabant M, Schmitz-Afonso I, Gallard JF, Menou JL, Laurent D, Debitus C, and Al-Mourabit A

Subjects
Animals, Drug Screening Assays, Antitumor, Glycosides chemistry, Glycosides pharmacology, Humans, KB Cells, Marine Biology, Melanesia, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Pregnanes chemistry, Pregnanes pharmacology, Saponins chemistry, Saponins pharmacology, Sulfuric Acid Esters chemistry, Sulfuric Acid Esters pharmacology, Glycosides isolation & purification, Porifera chemistry, Pregnanes isolation & purification, Saponins isolation & purification, Sulfuric Acid Esters isolation & purification
Abstract

Three new pregnanes, ptilosteroid A (1), ptilosteroid B (2), and ptilosteroid C (3), and two new pregnane glycosides, ptilosaponoside A (4) and ptilosaponoside B (5), were isolated from the marine sponge Ptilocaulis spiculifer collected in the Solomon Islands. The structures were determined by spectroscopic methods. Biological tests of these compounds showed that they are not cytotoxic against KB cells.

Published
2009
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